Biomolecular medicine

The nano-scale spatial organization of metallic and other inorganic materi-als into 1D objects is a key task in nanotechnology. Nano-scale fibers and tubes are very useful templates for such organization because of their inherent 1D organization. Fibrillar biological molecules and biomolecular assemblies are excellent physical supports on which to organize the inor-ganic material.

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With the amount of genetic information available, a lot of attention has focused on systems biology, in particular biomolecular interactions. Con-sidering the huge number of such interactions, and their often weak and transient nature, conventional experimental methods such as X-ray crystal-lography and NMR spectroscopy are not sufficient to gain structural insight into these. A wealth of biochemical and⁄or biophysical data can, however, readily be obtained for biomolecular complexes.

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Molecular identification of adrenal inner zone antigen as a heme-binding protein Li Min1*, Natallia V. Strushkevich1,2*, Ivan N. Harnastai2, Hiroko Iwamoto3, Andrei A. Gilep1,2, Hiroshi Takemori1, Sergey A. Usanov2, Yasuki Nonaka3, Hiroshi Hori4, Gavin P.

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Welcome to the home of the online edition of The Cancer Handbook which provides a comprehensive overview of all major areas of cancer research and oncology. This title differs from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. ...

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Laboratory for Lipoprotein Chemistry and 4Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine, Department of Biochemistry, Ghent University, Belgium; 2Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, Belgium; 3Ecole Normale Supe´rieure, Paris, France Penetratin is a 16-amino-acid peptide, derived from the homeodomain of antennapedia, a Drosophila transcription factor, which can be used as a vector for the intracellular delivery of peptides or oligonucleotides....

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Less than twenty years ago photolithography and medicine were total strangers to one another. They had not yet met, and not even looking each other up in the classifieds. And then, nucleic acid chips, microfluidics and microarrays entered the scene, and rapidly these strangers became indispensable partners in biomedicine. As recently as ten years ago the notion of applying nanotechnology to the fight against dis- ease was dominantly the province of the fiction writers.

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A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide ´ Dominic M. Walsh1, Eva Thulin2, Aedın M. Minogue1, Niklas Gustavsson3, Eric Pang4, David B.

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A majority of human proteins have a modular composition, and are constructed of domains that mediate biomolecular inter-actions, and in some cases have catalytic functions. Interaction domains (i.e. SH2 domains) can regulate catalytic activity, direct enzymes to their substrates, and mediate the formation of multi-protein regulatory complexes, and of extended protein net-works. The functions of such modular protein interactions in phosphotyrosine-based signaling pathways, cytoskeletal organ-ization and cell polarity will be explored.

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Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway – evidence of a different substrate specificity Nicola Barison1,2, Laura Cendron1,2, Alberto Trento2, Alessandro Angelini2,* and Giuseppe Zanotti1,2,3 1 Department of Biological Chemistry, University of Padua, Italy 2 Venetian Institute of Molecular Medicine (VIMM), Padua, Italy 3 Institute of Biomolecular Chemistry of CNR, Padua, Italy Keywords Helicobacter pylori; stomach colonization; thiamin; thiaminase; vitamin B1 Correspondence G.

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Jeffrey A Bailey*, Robert Baertsch†, W James Kent†, David Haussler‡ and Evan E Eichler* Addresses: *Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. †Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA. ‡Howard Hughes Medical Institute, 321 Baskin Engineering, University of California, Santa Cruz, CA 95064, USA. Correspondence: Evan E Eichler. E-mail: eee@cwru.

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