Xem 1-12 trên 12 kết quả Cell lysis
  • Mistletoe extracts have immunomodulatory activity. We show that nontoxic concentrations ofViscumalbumextracts increase natural killer (NK) cell-mediated killing of tumor cells but spare nontarget cells from NK lysis. The com-pounds responsible for this bioactivity were isolated from mistletoe and characterized. They have low molecular mass and are thermostable and protease-resistant.

    pdf10p research12 29-04-2013 11 1   Download

  • The advances of microelectromechanical systems (MEMS) and devices have been instrumental in the demonstration of new devices and applications, and even in the creation of new fields of research and development: bioMEMS, actuators, microfluidic devices, RF and optical MEMS. Experience indicates a need for MEMS book covering these materials as well as the most important process steps in bulk micro-machining and modeling. We are very pleased to present this book that contains 18 chapters, written by the experts in the field of MEMS. ...

    pdf0p qsczaxewd 22-09-2012 27 8   Download

  • Actinoporins are a family of sea anemone proteins that bind to membranes and produce functional pores which result in cell lysis. Actinoporin vari-ants with decreased lytic activity usually show a reduced affinity for mem-branes.

    pdf10p cosis54 05-01-2013 18 3   Download

  • Infection of epithelium with human papillomavirus (HPV) 16 is generally prolonged, suggesting an ineffective virus-specific immune response, and prolonged infection promotes anogenital cancer. To determine whether poor antigen presentation by HPV-infected keratinocytes (KCs) contributes to prolonged HPV infection

    pdf9p mobifone23 08-01-2013 9 2   Download

  • The ATP-sensitive potassium (KATP) channel couples glucose metabolism to insulin secretion in pancreatic b-cells. It comprises regulatory sulfonyl-urea receptor 1 and pore-forming Kir6.2 subunits. Binding and⁄or hydro-lysis of Mg-nucleotides at the nucleotide-binding domains of sulfonylurea receptor 1 stimulates channel opening and leads to membrane hyperpolari-zation and inhibition of insulin secretion.

    pdf13p galaxyss3 19-03-2013 13 2   Download

  • To facilitate the process of proteindesign and learn the basic rules that control the structure and stability of proteins, combinatorial methods have been developed to select or screen proteins with desired properties from libraries of mutants. One such method uses phage-display and proteo-lysis to select stably folded proteins. This method does not rely on specific properties of proteins for selection. There-fore, in principle it can be applied to any protein.

    pdf6p dell39 03-04-2013 9 2   Download

  • The sensitive to lysis D (SlyD) protein fromEscherichia coliis related to the FK506-binding protein family, and it harbours both peptidyl-prolyl cis–transisomerase (PPIase) and chaperone-like activity, preventing aggre-gation and promoting the correct folding of other proteins. Whereas a functional role of SlyD as a protein-folding catalyst in vivo remains unclear, SlyD has been shown to be an essential component for [Ni–Fe]-hydrogenase metallocentre assembly in bacteria.

    pdf16p vinaphone15 25-02-2013 8 1   Download

  • The role of vertebrate histone proteins or histone derived peptides as innate immune effectors has only recently been appreciated. In this study, high levelsof corehistoneproteins H2A, H2B, H3 and H4 were found in hemocytes from the Pacific white shrimp,Litopenaeus vannamei. The proteins were identified by in-gel digestion, mass spectrometry ana-lysis, and homology searching. The L. vannameihistone proteins were found to be highly homologous to histones of other species.

    pdf0p awards 05-04-2013 7 1   Download

  • Ribosomes position their substrate at stereochemistry suitable for peptide bond formation, and promote substrate-mediated cata-lysis. The linkage between substrate orientation, dominated by remote interactions, and a sizable symmetrical region identified in all known ribosome structures indicates a guided rotatory motion of aminoacylated-tRNAs along a ribosomal path leadings to the advance of nascent peptides into the protein exit tunnel at an extended conformation.

    pdf4p fptmusic 11-04-2013 8 1   Download

  • Plasmin(ogen) kringles 1 and 4 are involved in anchorage of plasmin(ogen) to fibrin and cells, an essential step in fibrinolysis and pericellular proteo-lysis. Their contribution to these processes was investigated by selective neutralization of their lysine-binding function. Blocking the kringle 1 lysine-binding site with monoclonal antibody 34D3 fully abolished binding and activation of Glu-plasminogen and prevented both fibrinolysis and plasmin-induced cell detachment-induced apoptosis.

    pdf14p fptmusic 11-04-2013 7 1   Download

  • Recently, the CPS biosynthetic loci for several strains ofCampylobacter jejuni were sequenced and revealed evidence for multiple mechanisms of structural variation. In this study, the CPS structure for the HS:1 serostrain of C. jejuni was determined using mass spectrometry and NMR at 600 MHz equipped with an ultra-sensitive cryogenically cooled probe. Ana-lysis of CPS purified using a mild enzymatic method revealed a teichoic acid-like [-4)-a-d-Galp-(1–2)-(R)-Gro-(1-P]n, repeating unit, where Gro is glycerol....

    pdf16p fptmusic 11-04-2013 8 1   Download

  • Inhibition of Cell-Wall Synthesis One major difference between bacterial and mammalian cells is the presence in bacteria of a rigid wall external to the cell membrane. The wall protects bacterial cells from osmotic rupture, which would result from the cell's usual marked hyperosmolarity (by up to 20 atm) relative to the host environment. The structure conferring cell-wall rigidity and resistance to osmotic lysis in both gram-positive and gram-negative bacteria is peptidoglycan, a large, covalently linked sacculus that surrounds the bacterium.

    pdf7p colgate_colgate 21-12-2010 31 1   Download

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