Glutathione conjugation

Xem 1-6 trên 6 kết quả Glutathione conjugation
  • The nature of cGMP transport in human erythrocytes, its relationship to glutathione conjugate transport, and pos-sible mediation by multidrug resistance-associated proteins (MRPs) have been investigated. MRP1, MRP4 and MRP5 are detected in immunoblotting studies with erythrocytes. MRP1and MRP5 are also detected in multidrug resistant COR-L23/R and MOR/R cells but at greatly reduced levels in the parent, drug sensitive COR-L23/P cells. MRP4 is detected in MOR/R but not COR-L23/R cells.

    pdf13p tumor12 20-04-2013 11 2   Download

  • GlutathioneS-transferases (GSTs) catalyze the conjugation of glutathione to hydrophobic compounds, contributing to the metabolism of toxic chemicals. In this study, we show that two naturally occurring tau GSTs (GSTUs) exhibit distinctive kinetic parameters towards 1-chloro-2,4-dini-trobenzene (CDNB), although they differ only in three amino acids (Arg89, Glu117 and Ile172 in GSTU1 are replaced by Pro89, Lys117 and Val172 in GSTU2).

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  • What is ‘biochemical pharmacology’? • A fancy way of saying ‘pharmacology’, and of hiding the fact that we are sneaking a subject of medical interest into the UW biochemistry curriculum. • An indication that we are not going to discuss prescriptions for your grandmother’s aching knee; we will focus on the scientific side of things but not on whether to take the small blue pill before or after the meal. What is it not? • A claim that we accurately understand the mechanism of action of each practically useful drug in biochemical terms.

    pdf0p mnemosyne75 02-02-2013 27 2   Download

  • The human multidrug resistance-associated protein (MRP1) is an ATP-dependent efflux pump that transports anionic conjugates, and hydrophobic compounds in a glutathione dependent manner. Similar to the other, well-characterized multidrug transporter P-gp, MRP1 comprises two nucleotide-binding domains (NBDs) in addition to transmembrane domains. However, whereas the NBDs of P-gp have been shown to be functionally equivalent, those of MRP1 differ significantly.

    pdf9p research12 01-06-2013 6 2   Download

  • Glutathione (GSH) conjugating enzymes, glutathioneS-transferases (GSTs), are present in different subcellular compartments including cytosol, mitochondria, endoplasmic reticulum, nucleus and plasma membrane. The regulation and function of GSTs have implications in cell growth, oxidative stress as well as disease progression and prevention.

    pdf9p cosis54 09-12-2012 19 1   Download

  • TheSaccharomyces cerevisiae vacuolar ATP-binding cassette transporter Ycf1p is involved in heavy metal detoxification by mediating the ATP-dependent transport of glutathione–metal conjugates to the vacuole. In the case of selenite toxicity, deletion of YCF1was shown to confer increased resistance, rather than sensitivity

    pdf10p cosis54 09-12-2012 6 1   Download

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