
Journal of Physical Science, Vol. 21(1), 79–92, 2010 79
Evaluation of In Vitro Antioxidant Activity of
Vd Nagaraja Naik1*
1D re, Manasagangotri
. College,
Acharya 57, Andhra Pradesh, India
ara University,
dia
ing different
valuated for
ry activity on
ty in an egg
ong the compounds, (a) and (d) significantly inhibited human
(e) and (f)
were used
reference antioxidant compounds. Comparative studies with the synthesised
compounds were also performed.
LDL oxidation, lipid peroxidation, antioxidant
elated with
cancer and
are gaining
f preventive
lly useful
e generated
in various
components of the body (e.g., lipids, proteins and nucleic acids) and may also be
involved in processes leading to the formation of mutations. Furthermore, radical
reactions play a significant role in the development of life-limiting chronic
diseases such as cancer, diabetes, arteriosclerosis and others.6 It has been
suggested that oxidative modification of low-density lipoproteins (LDLs) may
play a role in the development of atherosclerosis.7 The oxidative modification
5H-dibenz[b,f]azepine and Its Analogues
ijay Kumar Honnaiah1, Ranga Rao Ambati2, Varakumar Sadineni3 an
epartment of Studies in Chemistry, University of Myso
Mysore – 570 006, Karnataka, India
2D Y. R. Nepartment of Oils and Fats, V. R. S. &
Nagarjuna University, Chirala – 523 1
3Department of Biochemistry, Sri Venkatesw
Tirupati – 5 7 502, Andhra Pradesh, In1
*Corresponding author: drnaik_chem@yahoo.co.in
Abstract: Synthesis of 5H-dibenz[b,f]azepine and its derivatives bear
functional groups was performed. The compounds thus synthesised were e
their antioxidant activities by following two well established assays: inhibito
human low density lipoprotein (LDL) oxidation and lipid peroxidation activi
liposome model system. Am
LDL oxidation and liposome peroxidation, whereas compounds (b), (c),
showed less activity. Butylated hydroxy anisole (BHA) and ascorbic acid (AA)
as
Key
acti
words: 5H-dibenz[b,f]azepine,
vity
1. INTRODUCTION
Free radicals and active oxygen species have been corr
cardiovascular and inflammatory diseases and even with a role in
ageing.1,2 Efforts to counteract the damage caused by these species
acceptance as a basis for novel therapeutic approaches, and the field o
medicine is experiencing an upsurge of interest in medica
antioxidants.3,4 Recent evidence5 suggests that free radicals, which ar
in many bioorganic redox processes, may induce oxidative damage