Báo cáo khoa học: Synthetic constrained peptide selectively binds and antagonizes death receptor 5
Apoptosis or programmed cell death is an inherent part of the development
and homeostasis of multicellular organisms. Dysregulation of apoptosis is
implicated in the pathogenesis of diseases such as cancer, neurodegenera-tive diseases and autoimmune disorders. Tumour necrosis factor-related
apoptosis-inducing ligand (TRAIL) is able to induce apoptosis by binding
death receptor (DR)4 (TRAIL-R1) and DR5 (TRAIL-R2), which makes
TRAIL an interesting and promising therapeutic target.