báo cáo khoa hoc : The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis

Human guanylate-binding protein 1 (hGBP1) belongs to the superfamily of large, dynamin-related GTPases. The expression of hGBP1 is induced by stimulation with interferons (mainly interferon-c), and it plays a role in dif-ferent cellular responses to inflammatory cytokines, e.g. pathogen defence, control of proliferation, and angiogenesis.