Summary of Organic Chemistry doctoral thesis: Synthesis and evaluation of anticancer activity of tubulysin derivatives

Aim of the thesis: Synthesis of several derivatives and tubulysin analogues with the replacement of the amino acid methylpipecolic (Mep) at the N-terminal, replacing N,O-acetyl group by methyl group, and researching the role of tubuphenylalanine (Tup) group at the C-terminal.