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Synthesis of new coumarin derivatives and evaluation of their anti-cancer activity

A fragment-based approach has been applied to derive 2-(7-hydroxy-2-oxo-2H-chromen-4- yl)acetic acid 1 into 4 new coumarin derivatives 2a-d through amide bonds. The compounds were screened for their anticancer activity using MTT assay on MCF-7 and HepG2 cell lines.

viaburame

14/03/2025

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Bioactive constituents of Goniothalamus tamirensis essential oil and its anticancer activity

Bioactive constituents of Goniothalamus tamirensis essential oil and its anticancer activity

Optimization of extraction of flavonoid and polyphenol from Camellia megasepala leaves and their anticancer activity

Optimization of extraction of flavonoid and polyphenol from Camellia megasepala leaves and their anticancer activity

2D-QSAR and molecular docking studies of hydroxamic acid derivatives bearing Benzimidazole scaffold as histone deacetylase 6 inhibitors

2D-QSAR and molecular docking studies of hydroxamic acid derivatives bearing Benzimidazole scaffold as histone deacetylase 6 inhibitors

In silico design, 2D-QSAR study, pharmacophore modeling and molecular docking of novel glutaminyl cyclase inhibitors

In silico design, 2D-QSAR study, pharmacophore modeling and molecular docking of novel glutaminyl cyclase inhibitors

Synthesis and evaluation of the acetylcholinesterase inhibitory effect of novel heteroaromatic derivatives bearing a 2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetamide scaffold

Synthesis and evaluation of the acetylcholinesterase inhibitory effect of novel heteroaromatic derivatives bearing a 2-(5-(pyridin-2-yl)-1H-tetrazol-1-yl)acetamide scaffold

Therapeutic effects and mechanism of Panax ginseng in improving spermatogenesis: Evidence from network pharmacology and molecular docking

Therapeutic effects and mechanism of Panax ginseng in improving spermatogenesis: Evidence from network pharmacology and molecular docking

Evaluation of in silico andiabec acvity of phytocompounds of wild bier gourd on DPP4 target

Evaluation of in silico andiabec acvity of phytocompounds of wild bier gourd on DPP4 target

Molecular docking study of anticancer activity of some s-triazine derivatives as HDAC6 inhibitors

Molecular docking study of anticancer activity of some s-triazine derivatives as HDAC6 inhibitors

Evaluation of in silico anticancer activity of some striazine derivatives as VEGFR2 inhibitors

Evaluation of in silico anticancer activity of some striazine derivatives as VEGFR2 inhibitors

Master's thesis of Science: Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

Master's thesis of Science: Investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

Summary of Organic Chemistry doctoral thesis: Synthesis and evaluation of anticancer activity of tubulysin derivatives

Summary of Organic Chemistry doctoral thesis: Synthesis and evaluation of anticancer activity of tubulysin derivatives

Summary of Chemistry doctoral thesis: Synthesis and evaluation of anticancer activity of tubulysin derivatives

Summary of Chemistry doctoral thesis: Synthesis and evaluation of anticancer activity of tubulysin derivatives

Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

O-Substituted N(3)-benzyl analogs of vitamin B1 as inhibitors of acetylcholinesterase or butyrylcholinesterase

O-Substituted N(3)-benzyl analogs of vitamin B1 as inhibitors of acetylcholinesterase or butyrylcholinesterase

Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modiﬁcations

Báo cáo khoa học: nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modiﬁcations

Báo cáo khóa học: Binding analyses between Human PPARc–LBD and ligands Surface plasmon resonance biosensor assay correlating with circular dichroic spectroscopy determination and molecular docking

Báo cáo khóa học: Binding analyses between Human PPARc–LBD and ligands Surface plasmon resonance biosensor assay correlating with circular dichroic spectroscopy determination and molecular docking

báo cáo khoa học: "Anticancer activity of the iron facilitator LS081"

báo cáo khoa học: "Anticancer activity of the iron facilitator LS081"

Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies"

Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies"

Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

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