Chapter 056. Cutaneous Drug Reactions (Part 8)

Allopurinol Together with sulfonamides and antiepileptics, allopurinol is one of the "usual suspects" that induce frequently mild maculopapular eruptions (in at least 3% of users) and may also cause more severe reactions including hypersensitivity/DRESS and SJS/TEN. Because of increasing utilization it is one of the most frequent causes of life-threatening reactions. Anti-HIV Medications In clinical trials, combinations of highly active antiretroviral treatments were frequently associated with ≥10% "drug eruptions." Two drugs, nevirapine and abacavir, have been associated with specific risks. Nevirapine has both a high risk of maculopapular eruptions and a very high risk (about 1 in 1000) of SJS or TEN. Progressive escalation...