Mothers’ Investments in Child Health in the U.S. and U.K.: A Comparative Lens on the Immigrant 'Paradox'
Hydroxyurea’s efficacy in sickle cell disease is generally attributed to its ability to raise the
levels of Hb F in the blood; however, the mechanisms by which it does so are unclear. Early
studies suggested that hydroxyurea is cytotoxic to the more rapidly dividing late erythroid
precursors, resulting in the recruitment of early erythroid precursors with an increased capacity
to produce Hb F. One recent study supports a nitric oxide-derived mechanism for the induction
of Hb F by hydroxyurea, and another study suggests that ribonucleotide reductase inhibition is
responsible for this increase in Hb F. Alternatively, hydroxyurea may be...
