Stem cells
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The process of neural stem cell (NSC) differentiation into neurons is crucial for the development of potential cell-centered treatments for central nervous system disorders. However, predicting, identifying, and anticipating this differentiation is complex. In this study, we propose the implementation of a convolutional neural network model for the predictable recognition of NSC fate, utilizing single-cell brightfield images.
7p viengfa 28-10-2024 2 2 Download
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To evaluate the changes of clinical and paraclinical characteristics in chronic obstructive pulmonary disease patients after treatment of umbilical cord-derived mesenchymal stem cells. Subjects and method: 21 stable COPD patients were enrolled with C and D groups in accordance with GOLD 2018.
7p viengfa 28-10-2024 2 2 Download
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In this study, we tested the ability of a specific culture medium supplemented with a cytokine cocktail to increase the number of total MNCs and thereby enrich CD34+UCHSCs. In addition, we investigated the effects of the bioactive peptide SL-13R on the proliferation of CD34+UC-HSCs at different culture time points and peptide doses.
7p xuanphongdacy06 18-09-2024 4 1 Download
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High-risk neuroblastoma is a childhood malignancy with a poor prognosis. Gradual improvements in survival have correlated with therapeutic intensity, and the ability to harvest, process and store autologous hematopoietic stem cells has allowed for dose intensification beyond marrow tolerance.
5p vinatisu 29-08-2024 1 1 Download
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Bài viết Tế bào gốc và tế bào gốc trung mô: Cơ chế và áp dụng trong lâm sàng trình bày các nội dung: Đại cương về tế bào gốc; Phân loại tế bào gốc; Tế bào gốc trung mô (Mesenchymal Stem Cells - MSCs); Đặc điểm MSCs người; Chức năng của MSCs; Cơ chế homing của MSCs.
12p viambani 18-06-2024 9 2 Download
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Tế bào gốc trung mô (Mesenchymal stem cells, MSCs) là các tế bào đa năng có thể tự làm mới và tiết ra nhiều yếu tố sinh học để hồi phục và sửa chữa các mô bị tổn thương. Bài viết này tập trung chủ yếu vào vai trò của MSCs trong điều trị T1D.
10p vibranson 06-12-2023 11 3 Download
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Bài viết trình bày đánh giá hiệu quả của tế bào gốc từ mô mỡ tự thân (Adipose - Derived Stem Cells - ADSCs) kết hợp với huyết tương giàu tiểu cầu (Platelet Rich Plasma - PRP) lên biến đổi tại chỗ vết thương mạn tính và một số marker sinh học.
8p visoros 01-11-2023 9 2 Download
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Bài viết Đánh giá bệnh tồn lưu tối thiểu sau tự ghép tủy trong điều trị đa u tủy bằng phương pháp tế bào dòng chảy nghiên cứu nhằm đánh giá MRD bằng phương pháp MFC sau tự ghép tủy (Autologous stem cell transplant - ASCT) để có cái nhìn tổng quát về vai trò của MRD sau điều trị.
10p vifred 23-12-2022 23 3 Download
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Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities need to be identified.
25p vimichaelfaraday 25-03-2022 24 1 Download
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Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. However, a comprehensive single-cell level differentiation roadmap for hPSCs has not been achieved.
19p vimichaelfaraday 25-03-2022 14 1 Download
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A new study reveals comprehensive and unique epigenetic properties of glioma stem cells, leading to novel molecular insights and therapeutic potentials toward glioblastoma multiforme treatment.
3p vimichaelfaraday 25-03-2022 11 1 Download
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Osteosarcoma (OS) is a differentiation disease caused by the genetic and epigenetic differentiation of mesenchymal stem cells into osteoblasts. OS is a common, highly malignant tumor in children and adolescents. Fifteen to 20 % of the patients find distant metastases at their first visit.
13p vielonmusk 21-01-2022 21 0 Download
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Loss of prostate cancer differentiation or de-differentiation leads to an untreatable disease. Patient survival would benefit if this can be prevented or reversed. Cancer de-differentiation transforms luminal-like (differentiated) adenocarcinoma into less luminal-like and more stem-like (undifferentiated) small cell carcinoma through a sequential activation of stem cell transcription factors (scTF) POU5F1, LIN28A, SOX2 and NANOG.
13p vielonmusk 21-01-2022 11 0 Download
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The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rear‑ ranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) with a normal karyotype and in 5-6% of myelodysplastic syndrome (MDS) patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently one of the curative therapies available for AML and MDS with excess blasts (MDS-EB).
11p vielonmusk 21-01-2022 11 1 Download
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The osteogenic differentiation markers BMP2, BMP4, COL1A1, OPN, OCN and PF4 evaluated using RT-PCR. The tumor dimensions in the hMSCs group were significantly higher than those of the remaining groups (p < 0.01). The number of metastatic foci in the BMP2+hMSCs group was significantly lower than those of the other groups (p < 0.01). The current results showed that the intraperitoneal route could be efficiently used for targeting hMSCs to the tumoral tissues for effective BMP2 delivery.
13p thiencuuchu 27-11-2021 15 1 Download
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Understanding of the functions of microRNAs in breast cancer and breast cancer stem cells have been a hope for the development of new molecular targeted therapies. Here, it is aimed to investigate the differences in the expression levels of let-7a, miR10b, miR-21, miR-125b, miR-145, miR-155, miR-200c, miR-221, miR-222 and miR-335, which associated with gene and proteins in MCF-7 (parental) and MCF-7s (Mammosphere/stem cell-enriched population/CD44+/CD24-cells) cells treated with paclitaxel. MCF7s were obtained from parental MCF-7 cells.
12p thiencuuchu 27-11-2021 16 2 Download
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Tế bào gốc là tế bào có khả năng hóa thành các tế bào khác nhau để thay thế cho tế bào già và chết tự nhiên hay do chấn thương vì nhiều nguyên nhân khác nhau, mở ra triển vọng sử dụng TBG to tái tạo lại các mô. Ghép TBG từ tuỷ xương tự thân đã được sử dụng trên lâm sàng để điều trị thành công các trường cắt đứt liên kết lâu dài và giả mạo. Khi được tiêm vào xương gãy, xương TBG sẽ hóa thành tế bào dạng xương (TBDTX), tái tạo lại ố khuyết xương. Mời các bạn cùng tìm hiểu nội dung bài báo.
8p closefriend02 07-10-2021 34 3 Download
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The aim of this thesis was to gain an understanding of how the simulated microgravity condition affects the development of hucMSC by investigating the changes in cell morphology, proliferation and cytoskeleton structure of hucMSCs under in vitro condition.
27p beloveinhouse01 15-08-2021 19 4 Download
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That is cause we conducted this thesis, which has two subjects as follows: Describing some clinical and para-clinical characteristics and histology of chronic wound. Evaluating the effective of autologous adipose tissue derived stem cell transplation in chronic wound treatment.
23p petsematary 02-06-2021 16 3 Download
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Fibroblast growth factor-2 (FGF-2) is a multifunctional protein that plays an important role in the regulation of proliferation, differentiation and migration of a variety of cells. The recombinant human FGF-2 (rhFGF-2) is currently used in stem cell culture, medicine and cosmetic products. In this study, we aim to produce secreted rhFGF-2 protein from a Pichia pastoris strain containing multiple copies of the fgf-2 gene to eliminate the disadvantages of intracellular expression systems
9p larachdumlanat127 02-01-2021 13 2 Download