Báo cáo khoa học: Oxidase activity of a flavin-dependent thymidylate synthase
Flavin-dependent thymidylate synthases (FDTS) catalyze the production of
dTMP from dUMP and N
5
,N
10
-methylene-5,6,7,8-tetrahydrofolate
(CH2H4
folate). In contrast to human and other classical thymidylate synth-ases, the activity of FDTS depends on a FAD coenzyme, and its catalytic
mechanism is very different.