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Simulation-based benchmarking of isoform quantification in single-cell RNA-seq

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Single-cell RNA-seq has the potential to facilitate isoform quantification as the confounding factor of a mixed population of cells is eliminated. However, best practice for using existing quantification methods has not been established. We carry out a benchmark for five popular isoform quantification tools. Performance is generally good for simulated data based on SMARTer and SMART-seq2 data.

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Nội dung Text: Simulation-based benchmarking of isoform quantification in single-cell RNA-seq

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