Biological roles

Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress. In vitro CTC clusters model can help to further understand the biological properties of CTC clusters and their clinical significance.

17p vishanshan 27-06-2024 1 1   Download

One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been widely reported to be correlated with tumorigenesis and therapeutic response. This study aimed to explore the biological role of eIF3a, evaluate its prognostic and therapeutic potential in DLBCL.

16p vishanshan 27-06-2024 2 1   Download

Accumulating evidence indicates that aberrant non-SMC condensin II complex subunit D3 (NCAPD3) is associated with carcinogenesis of various cancers. Nevertheless, the biological role of NCAPD3 in the pathogenesis of non-small cell lung cancer (NSCLC) remains unclear.

12p vishanshan 27-06-2024 1 1   Download

Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of glioma. In order to investigate the biological role of RTEL1 in glioma.

15p vishanshan 27-06-2024 1 1   Download

Since the biological material that remains after diagnostic and therapeutic procedures plays crucial role in biobank research, this study aims to explore cancer patients’ views on the donation of biospecimens for research purposes.

13p vishanshan 27-06-2024 2 1   Download

Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.

15p vishanshan 27-06-2024 1 1   Download

Indigenous adolescents access primary health care services at lower rates, despite their greater health needs and experience of disadvantage. This systematic review identifies the enablers and barriers to primary health care access for Indigenous adolescents to inform service and policy improvements.

29p vishanshan 27-06-2024 1 1   Download

Lung adenocarcinoma (LUAD) is a non-small cell carcinoma. Ribonuclease/angiogenin inhibitor 1 (RNH1) exerts multiple roles in virous cancers. E2F1 is a critical transcription factor involved in the LUAD development. Here, we analyze the expression of RNH1 in LUAD patients, investigate the biological function of RNH1 in LUAD, and demonstrate its potential mechanisms through E2F1 in LUAD.

17p vikoch 27-06-2024 1 1   Download

NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.

22p vikoch 27-06-2024 3 1   Download

Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role of LDHs in pan-cancers.

20p vikoch 27-06-2024 1 1   Download

Part 1 book "Pediatric dialysis" includes content: Notes on the history of dialysis therapy in children, the biology of dialysis, the demographics of dialysis in children, chronic dialysis in developing countries, organization and management of a pediatric dialysis program, role of the advanced practice provider in a pediatric dialysis program,... and other contents.

554p dianmotminh03 17-06-2024 0 0   Download

Ebook "Systems medicine" guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action.

492p dongmelo 27-05-2024 6 2   Download

Ebook "Forkhead transcription factors: Vital elements in biology and medicine" provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders.

283p ladongphongthanh1008 22-04-2024 3 2   Download

Ebook "Notch signaling in embryology and cancer" is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer.

346p ladongphongthanh1008 22-04-2024 2 1   Download

Ebook "RNA interference from biology to therapeutics" addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers.

348p ladongphongthanh1008 22-04-2024 6 1   Download

The various intuitive reasoning types in many cases comprise the core of students’ misconceptions about concepts, procedures and phenomena that pertain to natural sciences. Some researchers support the existence of a relatively closer connection between the right hemisphere and intuitive thought, mainly due to a notably closer relation of individual intuitive cognitive processes with specific right hemisphere regions.

9p viarnault 25-04-2024 8 1   Download

Ebook "The neuropilins: Role and function in health and disease" covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.

236p ladongphongthanh1008 22-04-2024 9 4   Download

Ebook "Networking of chaperones by co-chaperones" describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets.

152p ladongphongthanh1008 22-04-2024 4 4   Download

Ebook "Eukaryotic membranes and cytoskeleton: Origins and evolution" discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective. Many of the chapters present original research data from comparative genomic surveys. The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow us to accurately reconstruct the cellular machineries present in the last common ancestor of eukaryotes.

159p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

222p ladongphongthanh1008 22-04-2024 1 1   Download