Cell death pathway

Ebook "Phase transitions in cell biology" should be suitable for anyone interested in the nature of biological function, particularly those who tire of lumbering along well trodden pathways of pursuit, and are eager to hear something fresh. The book is replete with fresh interpretations of familiar phenomena, and should serve as an excellent gateway to deeper understanding.

187p ladongphongthanh1008 22-04-2024 3 2   Download

Ebook "Necrotic cell death" presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

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Ebook "Systems biology of apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches.

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Ebook "Cell death signaling in cancer biology and treatment" is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described.

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Ebook "Programmed cell death in cancer progression and therapy (Advances in experimental medicine and biology, Volume 615)" give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents.

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Part 2 book "Molecular cell biology" includes content: Post transcriptional gene control and nuclear transport, signaling at the cell surface, signaling pathways that control gene activity, integration of signals and gene controls, moving proteins into membranes and organelles, vesicular traffic, secretion and endocytosis, metabolism and movement of lipids, microfilaments and intermediate filaments, microtubules, regulating the eukaryotic cell cycle, cell birth, lineage and death, cancer.

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Ebook "Oxidants in biology: A question of balance" focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

324p tachieuhoa 28-01-2024 2 2   Download

Part 3 book "Textbook of biochemistry - With clinical correlations" includes content: Lipid metabolism II - pathways of metabolism of special lipids; amino acid and heme metabolism; purine and pyrimidine nucleotide metabolism; metabolic interrelationships; biochemistry of hormones; molecular cell biology; cell cycle, programmed cell death and cancer; digestion and absorption of basic nutritional constituents; vitamins and minerals - requirements and function; macronutrients - metabolic effects and health implications.

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Ferroptosis is a newly classified form of regulated cell death with implications in various tumor progression pathways. However, the roles and mechanisms of ferroptosis-related genes in glioma remain unclear.

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Colorectal cancer is one of the most common cancer and the third leading cause of death worldwide. Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Several studies have reported that an increase in ROS production could affect the expression of proteins involved in ROS-scavenging, detoxification and drug resistance.

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The immunosuppressive PD-1/PD-L1 (programmed cell death-1/ programmed cell death ligand-1) signaling pathway is considered to play an important role in the pathogenesis of HBV infection.

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Clear cell renal cell carcinoma (ccRCC) is common in urinary system tumors. Cuproptosis is a nonapoptotic cell death pathway. Copper binds to fatty acylated mitochondrial proteins and activates various forms of cell death.

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Leukemic cell metabolism plays a significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the immune checkpoint ligands that do not only cause the immune escape of cancer cells, but also have some intracellular effects in these cells.

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Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects.

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Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibitor 5 (Api5), an inhibitor of apoptosis, is upregulated in cancers. Interestingly, Api5 is shown to regulate both apoptosis and cell proliferation.

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Part 1 book "Avian embryology" includes content: Operations on primitive streak stage avian embryos; quail–chick transplantations, other chimeras - quail–duck and mouse–chick; manipulations of neural crest cells or their migratory pathways; embryo slices and strips - guidance and adhesion assays in the avian embryo; embryo slices and strips - guidance and adhesion assays in the avian embryo; cell division, diverentiation, and death in avian embryos;.... and other contents.

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The programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response. Blocking this signaling pathway may reduce the damage, lower the virus titer in lung tissue, and alleviate the symptoms of infection to promote recovery.

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Glioblastoma (GBM) is considered the most malignant and devastating intracranial tumor without effective treatment. Autophagy, apoptosis, and necrosis, three classically known cell death pathways, can provide novel clinical and immunological insights, which may assist in designing personalized therapeutics.

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A major challenge in the treatment of liver cancer is that a large proportion of patients fail to achieve long-term disease control, with death from liver cancer cell migration and invasion. Acid-sensitive ion channel 1α (ASIC1α) is involved in the migration, invasion, and proliferation of liver cancer cells.

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High-mobility group box 1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and drug resistance. Its effect, however, on the expression of programmed death-ligand 1 (PD-L1) in breast cancer cells has not been investigated.

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