Diagnostics and treatment

Monoclonal antibodies (mAb) are used as therapeutics and for diagnostics of a variety of diseases, and novel antibodies are continuously being developed to find treatments for new diseases. Therefore, the manufacturing process must accommodate a range of mAb characteristics. Acid-sensitive mAbs can severely compromise product purity and yield in the purification process due to the potential formation of aggregates.

8p viginny 23-12-2022 9 3   Download

Ethiopia’s National Malaria Control and Elimination Program aims to diagnose all suspected malaria cases within 24 h of fever onset and provide prompt treatment for confirmed cases. This study explored psychosocial factors associated with no-, delayed- and prompt- care-seeking among female caregivers of children under five years with fever in rural Ethiopia.

11p viferrari 28-11-2022 6 2   Download

Continued part 1, part 2 of ebook "Medicolegal issues in obstetrics and gynaecology" provide readers with content about: general gynaecology; abdominal hysterectomy; diagnostic and operative laparoscopy; ectopic pregnancy and miscarriage; urogynaecology; vaginal repair and concurrent prolapse and continence surgery; colposuspension and autologous fascial sling; laparoscopic prolapse surgery; infertility, subfertility and the menopause; fertility testing and treatment decisions;... Please refer to the part 2 of ebook for details!

179p duonghoanglacnhi 07-11-2022 7 2   Download

With the advancement of diagnostic modalities, there is an increase in the number of individuals detected with thyroid nodules. There are multiple treatment options for the management of nontoxic benign nodular goiter. Radioactive iodine results in effective goiter size reduction which can be administered as out-patient basis and is an appropriate alternative for patients with higher risk for surgery.

7p viporsche 28-10-2022 3 1   Download

The National Comprehensive Cancer Network recommends that patients with hormone receptorpositive early breast cancer be considered for adjuvant endocrine therapy (ET) after primary treatment like surgical excision.

10p vikolindagrabar 27-07-2022 2 1   Download

With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong clinical evidence for the utility of DNA-sequencing-based HRD testing in ovarian cancer, and growing evidence in breast cancer, we present analytical validation of the Tempus HRD-DNA test.

17p visusanwojcicki 28-06-2022 7 1   Download

Thyroid cancer (THCA) is the most common endocrine malignancy and incidence is increasing. There is an urgent need to better understand the molecular differences between THCA tumors at different pathologic stages so appropriate diagnostic, prognostic, and treatment strategies can be applied.

12p visusanwojcicki 28-06-2022 10 1   Download

How to Define and Determine Reference Intervals in the Clinical Laboratory; Approved Guideline — Second Edition (NCCLS document C28-A2) is written for users of diagnostic laboratory tests. It offers a protocol for determining reference intervals that meet the minimum requirements for reliability and usefulness.

59p tailieucuibap 19-06-2022 13 1   Download

Early diagnosis of sepsis and its differentiation from the noninfective SIRS is very important in order that treatment can be initiated in a timely and appropriate way. In this study we investigated standard haematological and biochemical parameters and thromboelastography (TEG) in patients who had undergone surgical resection of the oesophagus to find out if changes in any of these parameters could help in early differentiation between SIRS and sepsis development.

7p viisaacnewton 26-04-2022 15 1   Download

Cognitive impairment is an important determinant in health care. In the acute hospital setting cognition has a strong impact on treatment and care. Cognitive impairment can negatively affect diagnostics and treatment success. However, little is known about the individual situation and specific risks of people with cognitive impairments during hospital stays.

14p vinobelprisen 26-03-2022 11 2   Download

Comorbidity between depression and cognitive impairment is common in older adults, increases the disease burden disproportionally, and leads to diagnostic uncertainty. Insight into individual daily associations between affect and cognitive performance may help in personalizing diagnosis and treatment decisions. Our objective was to get insight into the daily associations between affect and cognitive performance within individual older adults.

11p vinobelprisen 26-03-2022 5 2   Download

Arthroscopic surgery is described as a minimally invasive technique for diagnosis, exploration and treatment of joint disorders. It allows intraarticular structures to be assessed accurately, thereby improving the diagnostic capabilities, and it broadens the spectrum of surgical techniques feasible for treatment of articular pathologies in cattle.

10p vigandhi 23-02-2022 12 1   Download

Benign juvenile idiopathic epilepsy has been described in humans but rarely in animals. The objectives of the study were to describe the clinical signs, clinical data, imaging findings, genetic examinations, treatment, long-term outcome and prognosis in Iberian lynx with juvenile epilepsy. Medical records, video recordings and diagnostic data from 2005 to 2019 were reviewed.

9p vidarwin 23-02-2022 9 1   Download

Rabies kills approximately 59,000 people each year worldwide. Rapid and accurate diagnosis of rabies is important for instituting rapid containment measures and for advising the exposed people for postexposure treatment.

8p vigandhi 23-02-2022 9 1   Download

Neoplasm in South American camelids (SAC) are commonly described. The most frequently reported type of neoplasm are lymphomas and diference in the age sufering from lymphomas of and llamas is seen. This report describes a case of a solitary lymphoma in a 5 years and 9 month old llama mare displaying the approach of diagnostic imaging and successful surgical treatment.

8p vidarwin 22-02-2022 3 1   Download

Long non-coding RNA (LncRNA) HOTAIR was amplified and overexpressed in many human carcinomas, which could serve as a useful target for cancer early detection and treatment. The 99mTc radiolabeled antisense oligonucleotides (ASON) could visualize the expression of HOTAIR and provide a diagnostic value for malignant tumors.

10p vielonmusk 21-01-2022 7 0   Download

The report a case of a 7-year-old child with urolithiasis in autotransplanted kidney treated with minipercutaneous nephrolithotomy. The patient presented with hematuria and graft hydronephrosis. Diagnostic procedures revealed ureterolithiasis as a cause of obstruction and blood in urine. Mini-percutaneous nephrolithotomy was successfully performed and during surgery, all stone fragments were removed.

5p inception36 30-11-2021 9 0   Download

The study aimed to explore the additional value of repair of Lafosse I subscapularis injury compared with debridement in anterosuperior rotator cuff injury. Operative treatment can effectively lessen severity of pain in the patients, improve shoulder joint function, increase the range of motion of the shoulder joint and enhance the QoL in treating anterosuperior rotator cuff injury.

8p vimackenziebezos 30-11-2021 10 0   Download

Corticosteroid therapy (CST) prior to biopsy may hinder histopathological diagnosis in primary central nervous system lymphoma (PCNSL). Therefore, preoperative CST in patients with suspected PCNSL should be avoided if clinically possible. The aim of this study was thus to analyze the difference in the rate of diagnostic surgeries in PCNSL patients with and without preoperative CST.

10p vimahuateng 26-11-2021 7 0   Download

Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoid neoplasm among adults,and approximately 30–40% of patients will experience relapse while 5–10% will suffer from primary refractory disease caused by different mechanisms, including treatment-induced resistance.

12p vimahuateng 26-11-2021 4 0   Download