Immune system

The gut microbiota plays a crucial role in food digestion, enhances the host's immune system, and against pathogens. Numerous studies have been conducted on the microbiota of insects in general and honeybees in particular. However, studies have primarily focused on adult honeybees, with fewer studies dedicated to larvae. Despite being within the hive, honeybee larvae still possess their distinct microbiota.

8p viling 27-09-2024 4 2   Download

Many environmental factors have been reported to be associated with the risk of developing multiple sclerosis (MS), such as lack of exposure to sunlight, vitamin D deficiency, obesity, smoking, and infectious mononucleosis. Vitamin D deficiency has been shown to play a role in immune system function and may increase the risk of developing MS, although there are many confounding factors and inconsistent results. In this report, we evaluated vitamin D levels in newly diagnosed MS patients to determine the need for vitamin D supplementation.

4p viling 27-09-2024 3 2   Download

There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development.

16p vibransone 28-03-2024 6 2   Download

Intrusion Detection (ID) is one of the active branches in network security research field. Many technologies, such as neural networks, fuzzy logic and genetic algorithms have been applied in intrusion detection and the results are varied. In this thesis, an Artificial Immune System (AIS) based intrusion detection is explored. AIS is a bio-inspired computing paradigm that has been applied in many different areas including intrusion detection.

74p runthenight07 01-03-2023 8 2   Download

Two major areas of the scorecard development process were identified as having much capacity for improving credit scoring models. These are the application of 1) better classifiers and 2) variable selection techniques. However, the application of an artificial immune system for developing scorecards as well as the use of other variable selection techniques, other than stepwise regression, in credit scoring are quite limited as indicated by the scarcity of published materials in these two areas in the current literature.

210p runthenight04 02-02-2023 5 2   Download

The aims of the study "Characterising microbial and neuroimmune interactions in a mouse model of autism" are threefold: i) To characterize the influence of the R451C mutation on caecal enteric neuron organization; ii) To characterize the influence of the R451C mutation on caecal patch macrophage density and morphology; iii) To assess for alterations in gut microbes in different regions of the GI tract in the NL3R451C mouse model of autism.

83p runthenight04 02-02-2023 7 1   Download

The immune system recognizes and destroys cancer cells. However, cancer cells develop mecha‑ nisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g. HLA-G, PD-L1, CDX2) either alone or in combination with the relative presence of immune cells (CD3 and CD8 positive T-cells) in the tumour tissue may describe the cancer cells’ ability to escape eradication by the immune system.

19p vielonmusk 21-01-2022 12 1   Download

This study with the following objectives: Study some characteristics of immune disorders, analysis of association with target organ damage and activity level (SLEDAI score) in patients with severe systemic lupus erythematosus. Evaluation of treatment outcome of pulsed methylprednisolone therapy combined with baseline treatment after 12 weeks in patients with severe systemic lupus erythematosus.

34p petsematary 02-06-2021 26 4   Download

In this study, we conducted experiments to determine mRNA expression of above genes in PV patients by realtime-PCR and CA125 concentration by ELISA. Results showed that expression of klotho, LAG3, CTLA-4 and PD-1 genes was decreased in PV patients, indicating that the immune tolerance was inactivated in PV patients.

10p tamynhan10 24-10-2020 13 1   Download

Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.

5p caothientrangnguyen 09-05-2020 27 1   Download

In this paper, a novel method is presented to detect spam content on the web. It is based on classification and employs an idea from biology, namely, danger theory, to guide the use of different classifiers. The evaluation of content features of WEBSPAM-UK2007 data set using 10-fold cross-validation demonstrates that this method provides high evaluation criteria in detecting web spam.

13p byphasse043256 23-03-2019 27 1   Download

We present a novel data structure for extracting data from protected self set. That helps to produce all possible detectors, or a complete detector repertoire, with lower time and space complexities compare to recent novel approaches. Theoretical analysis and experimental results show that our approach is effective and feasible. These new valuable characteristics can make complex AIS have the highest ability to detect data changes and to reduce false detection.

5p cumeo2004 02-07-2018 29 0   Download

NFκB plays an important role in the immune system in all organisms. In this study, physicochemical properties and modelling of finfish NFκBIα protein was analysed using in silico approach. Finfish species: guppy (Poecilia reticulate), Bicolor damselfish (Stegastes partitus), Channel catfish (Ictalurus punctatus), Coelacanth (Latimeria chalumnae), and Australian ghostshark (Callorhinchus milii) were used in this study.

10p nganga_06 29-09-2015 53 3   Download

Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is composed of a single subunit that contains both the ferroxidase center residues, typical of mammalian H chains, and the carboxylate residues forming the micelle nucleation site, typical of mammalian L chains. Comparison of the amino-acid sequence with those available from lower vertebrates indicates that T. bernacchii ferritin can be classified as an M-type homopolymer. Interestingly, the T. bernacchii ferritin chain shows 85.7% identity with a coldinducible ferritin chain of the rainbow trout Salmo gairdneri....

7p system191 01-06-2013 32 4   Download

Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.

8p system191 01-06-2013 28 4   Download

To examine the role of the distal His42 residue in the catalytic mechanism of pea cytosolic ascorbate peroxidase, two site-directed variants were prepared in which His42 was replaced with alanine (H42A) or glutamic acid (H42E). Electronic spectra of the ferric derivatives of H42A and H42E (pH 7.0, l ¼ 0.10 M, 25.0 °C) revealed wavelength maxima [kmax (nm): 397, 509, % 540sh, 644 (H42A); 404, 516, % 538sh, 639 (H42E)] consistent with a predominantly fiveco-ordinate high-spin iron. The specific activity of H42E for oxidation of L-ascorbate (8.2 ± 0.

11p system191 01-06-2013 39 4   Download

The long uORF-burdened 5¢UTRs of many genes encoding regulatory proteins involved in cell growth and differentiation contain internal ribosomal entry site (IRES) elements. In a previous study we showed that utilization of the weak IRES of platelet-derived growth factor (PDGF2) is activated during megakaryocytic differentiation.

10p system191 01-06-2013 34 4   Download

Single-crystal X-ray structure determinations of the complex between the minor-groove binder distamycin and d(GGCCAATTGG) reveal two 1 : 1 binding modes which differ in the orientation of the drug molecule in the minor groove. The two crystals were grown from different crystallization conditions and found to diffract to 2.38 and ˚ 1.85 A, respectively. The structures were refined to completion using SHELXL-93, resulting in a residual R factor of ˚ 20.30% for the 2.38-A resolution structure (including 46 ˚ water molecules) and 19.74% for the 1.

10p system191 01-06-2013 29 5   Download

Departamento de Bioquı´mica y Biologı´a Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA Reduction potential determinations of K75E, E139K and E301A ferredoxin-NADP+ reductases provide valuable information concerning the factors that contribute to tune the flavin reduction potential. Thus, while E139 is not involved in such modulation, the K75 side-chain tunes the flavin potential by creating a defined environment that modulates the FAD conformation. ...

6p system191 01-06-2013 33 4   Download

Mice expressing a C-terminal fragment of the prion protein instead of wild-type prion protein die from massive neuronal degeneration within weeks of birth. The C-terminal region of PrPc (PrP121–231) expressed in these mice has an intrinsic neurotoxicity to cultured neurones. Unlike PrPSc, which is not neurotoxic to neurones lacking PrPc expression, PrP121–231 was more neurotoxic to PrPc-deficient cells. Human mutations E200K and F198S were found to enhance toxicity of PrP121–231 to PrP-knockout neurones and E200K enhanced toxicity to wild-type neurones.

10p system191 01-06-2013 30 4   Download