Inflammatory disease

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, especially in adolescents. There are many classifications of the disease severity, and the role of bacteria in the pathogenesis has been confirmed. This article evaluates the severity of acne through the Global Acne Grading System and Investigator’s Global Assessment, and the presence of bacteria in the pustule.

5p vihatake 06-01-2025 1 0   Download

Acne vulgaris is an inflammatory disease of the pilosebaceous unit, consisting of comedones, papules, pustules, nodules, and cysts. With the complexity of polymorphic nature, acne vulgaris is inherently difficult to assess and the measurement and grading of this condition is a recognized challenge for clinicians. This article presents a comprehensive preview of acne severity assessment according to timelines to give an overview of methods used to measure acne severity.

8p viharuno 03-01-2025 1 1   Download

Hypertension is one of the major causes of cardiovascular diseases in the world. Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth. The objectives of this study were to determine the association between hypertension and periodontal parameters in periodontitis patients.

6p viuchiha 03-01-2025 2 1   Download

Bài giảng Siêu âm chẩn đoán phần phụ (Trừ bướu buồng trứng) trình bày các nội dung sau: Giải phẫu (anatomy), nang chức năng buồng trứng (functional cyst), viêm nhiễm vùng chậu (pelvic inflammatory disease), nang bọc màng bụng (peritoneal inclusion cyst), xoắn buồng trứng (ovarian torsion), xoắn vòi trứng đơn thuần (isolated fallopian tube torsion), ứ máu vòi trứng (hematosalpinx), ung thư nguyên phát vòi trứng (primary fallopian carcinoma), ung thư di căn vòi trứng (metastasis to fallopian tube), tắc nghẽn vòi trứng (obstruction of the fallopian tube) và kết luận (conclusion).

145p enter_12 28-06-2013 318 81   Download

Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.

5p caothientrangnguyen 09-05-2020 29 2   Download

Bệnh viêm loét đại tràng chảy máu được xếp cùng với bệnh Crohn gọi chung là nhóm bệnh viêm ruột (Inflammatory Bowel Disease- IBD).

4p secrets_1 23-08-2013 89 4   Download

The transcription factor nuclear factorjB(NF-jB) is an activator of multiple cytokines, chemokines and adhesion molecules, which are important in inflammatory diseases such as asthma, and is consequently considered as an attractive therapeutic target. In the present study, a con-stitutively active dominant version of IjBa,IjBaDN, was introduced into A549 pulmonary cells by adenovirus-mediated delivery. The dominant IjB, but not a null viral vector, prevented the induction of NF-jB-dependent transcription by both tumor necrosis factora(TNFa)and interleukin-1b(IL-1b). ...

7p dell39 03-04-2013 36 4   Download

The macrophage is critical to the innate immune response and contributes to human diseases, including inflammatory arthritis and plaque formation in atherosclerosis. Vascular endothelial growth factor (VEGF) is an angio-genic cytokine that is produced by macrophages.

14p dell39 27-03-2013 40 4   Download

Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that affects 0.5–1% of the population. RA causes progressive joint destruction that leads to the restriction of activities of daily living and deterioration of quality of life.

7p galaxyss3 07-03-2013 32 3   Download

Lipopolysaccharide is a major constituent of the outer membrane of Gram-negative bacteria. It activates monocytes and macrophages to produce cytokines such as tumor necrosis factor-aand interleukins IL-1b and IL-6. These cytokines appear to be responsible for the neurotoxicity observed in peripheral nervous system inflammatory disease.

11p galaxyss3 07-03-2013 35 4   Download

Many cellular functions of lung fibroblasts are controlled by protease-acti-vated receptors (PARs). In fibrotic diseases, PAR-1 plays a major role in controlling fibroproliferative and inflammatory responses. Therefore, in these diseases, regulation of PAR-1 expression plays an important role.

11p galaxyss3 07-03-2013 36 4   Download

Ulcerative colitis (UC) is a gastrointestinal disorder characterized by an inflammatory process associated with mucosal damage. Many studies have shown that n-3 polyunsaturated fatty acids (PUFAs) possess anti-inflam-matory effects in inflammatory bowel disease.

10p media19 05-03-2013 38 5   Download

Matrix metalloproteinase-9 (MMP-9) displays a preference for a broad range of substrates including extracellular matrix proteins and cytokines. MMP-9 plays an important role in physiological processes, as well as in inflammatory diseases and numerous cancers.

13p media19 05-03-2013 34 1   Download

It has been well documented that both endogenous inflammatory mediator advanced glycation end products (AGEs) and exogenous inflammatory inducer lipopolysaccharide play key roles in the initiation and development of inflammatory diseases. However, the combined inflammation-stimulatory effect of AGEs and lipopolysaccharide on endothelial cells, and, further-more, the underlying signal transduction pathways involved, have not been fully elucidated.

9p vinaphone15 25-02-2013 31 2   Download

a-defensins are released from granules of leukocytes and are implicated in inflammatory and fibrotic lung diseases. In the present study, the effects of a-defensins on the proliferation and collagen synthesis of lung fibroblasts were examined. We found thata-defensin-1 and a-defensin-2 induced dose-dependent increases in the incorporation of 5-bromo-2¢-deoxy-uridine into newly synthesized DNA in two lines of human lung fibroblasts (HFL-1 and LL-86)

12p viettel02 20-02-2013 37 3   Download

The S100 proteins are 10–12 kDa EF-hand proteins that act as central reg-ulators in a multitude of cellular processes including cell survival, prolifera-tion, differentiation and motility. Consequently, many S100 proteins are implicated and display marked changes in their expression levels in many types of cancer, neurodegenerative disorders, inflammatory and autoim-mune diseases.

13p viettel02 19-02-2013 34 1   Download

Obesity is a low-grade chronic inflammatory disease associated with an increased number of macrophages (adipose tissue macrophages) in adipose tissue. Within the adipose tissue, adipose tissue macrophages are the major source of visfatin⁄pre-B-cell colony-enhancing factor⁄nicotinamide phos-phoribosyl transferase.

13p viettel02 19-02-2013 39 3   Download

The regulation of cytokines and pro-inflammatory genes is an absolute essentiality to combat inflammatory diseases. The present study investigated the effects of 4-O-chloroacetyl-2,3-di-O-acetyl-6-O-levulinoyl-b-d-glucopyr-anosyl]-(1-3)-1-O-(p-methoxyphenyl)-2-deoxy-2-N-trichloroacetyl-4,6-O-ben-zylidene-a-d-glucopyranoside (RSCL-0409), a novel small molecule Toll-like receptor (TLR) signalling antagonist, and its mechanism of action in human monocytic (THP-1) cells stimulated with lipopolysaccharide (LPS)....

14p mobifone23 18-01-2013 39 4   Download

Cathepsin G (CG) (EC 3.4.21.20) and chymase (EC 3.4.21.39) are two clo-sely-related chymotrypsin-like proteases that are released from cytoplasmic granules of activated mast cells and⁄or neutrophils. We investigated the potential for their substrate-binding subsites to discriminate between their substrate specificities, aiming to better understand their respective role dur-ing the progression of inflammatory diseases.

12p cosis54 04-01-2013 31 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases... .

10p thulanh27 13-12-2011 34 2   Download