Macromolecules

Translocation through the plasma membrane is a major limiting step for the cellular delivery of macromolecules. A promising strategy to overcome this problem consists in the chemical conjugation (or fusion) to cell penetrating peptides (CPP) derived from proteins able to cross the plasma membrane. A large number of di€erent cargo mol-ecules such as oligonucleotides, peptides, peptide nucleic acids, proteins or even nanoparticles have been internalized in cells by this strategy.

8p research12 23-04-2013 31 4   Download

The molecular masses of macromolecules and subunits of the extracellular hemoglobin from the fresh-water crustaceanDaphnia magnawere deter-mined by analytical ultracentrifugation, multiangle laser light scattering and electrospray ionization mass spectrometry.

18p inspiron33 25-03-2013 43 5   Download

The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors.

20p viettel02 19-02-2013 52 4   Download

Service de Conformation des Macromolécules Biologiques, Centre de Biologie Structurale et Bioinformatique, CP 263, Université Libre de Bruxelles, Bld du Triomphe, B-1050 Bruxelles, Belgium. †Institut Pasteur, Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, rue du Docteur Roux, 75724 Paris Cedex 15, France. Correspondence: Shoshana J Wodak. E-mail: shosh@ucmb.ulb.ac.be reviews Published: 30 April 2004 Genome Biology 2004, 5:R33 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2004/5/5/R33...

0p thulanh21 15-11-2011 35 1   Download