MAP kinase 1

Ampicillin has been widely used to treat bacterial infections. When we used ampicillin to eliminate bacterial contamination in yeast cultures, we observed induction of phosphorylation of MAP kinase 1 (Mpk1), a previously unknown function of ampicillin.

8p nutifooddau 27-01-2019 9 0   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Stimulation of MAP kinase pathways after maternal IL-1β exposure induces fetal lung fluid absorption in guinea pigs...

8p toshiba12 21-10-2011 24 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases...

10p toshiba13 21-10-2011 37 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Selective regulation of MAP kinases and Chemokine expression after ligation of ICAM-1 on human airway epithelial cells...

10p toshiba13 21-10-2011 33 2   Download

Amylin-mediated isletb-cell death is implicated in diabetogenesis. We pre-viously reported that fibrillogenic human amylin (hA) evokesb-cell apopto-sis through linked activation of Jun N-terminal kinase 1 (JNK 1) and a caspase cascade. Here we show that p38 kinase [p38 mitogen-activated pro-tein (MAP) kinase] became activated by hA treatment of cultured b-cells whereas extracellular signal-regulated kinase (ERK) did not;

13p inspiron33 25-03-2013 34 2   Download

Eph receptor tyrosine kinases regulate many important biological pro-cesses. In the present study, we explored the substrate specificity of the EphA4 receptor tyrosine kinase using peptide arrays. We define a consen-sus substrate motif for EphA4 and go on to identify and test a number of potential EphA4 substrates and map their putative site(s) of phosphoryla-tion.

11p media19 06-03-2013 33 2   Download

The newestmember of themitogenactivatedprotein (MAP) kinase family of proteins, extracellular signal regulated kinase 5 (ERK5; also known as big-mitogen activated kinase 1 or BMK1) is widely expressed in many tissues including the brain. Although growth factor activation of ERK5 innon-neuronal cells has been shown to contribute to cell proliferation, differentiation and transformation, until recently no information was available on the role of ERK5 in neuronalsurvival.

4p dell39 03-04-2013 37 2   Download

General and simple principles are identified that govern signal transduc-tion. The effects of kinase and phosphatase inhibition on a MAP kinase pathway are first examinedin silico. Quantitative measures for the control of signal amplitude, duration and integral strength are introduced. We then identify and prove new principles, such that total control on signal ampli-tude and on final signal strength must amount to zero, and total control on signal duration and on integral signal intensity must equal)1.

15p awards 05-04-2013 32 2   Download

InArabidopsis thaliana, the serine⁄threonine protein kinase oxidative signal-inducible 1 (OXI1), mediates oxidative stress signalling. Its activity is required for full activation of the mitogen-activated protein kinases (MAP-Ks), MPK3 and MPK6, in response to oxidative stress.

11p cosis54 05-01-2013 31 1   Download

The promoter of the early growth response gene (Egr-1) has been described to be activated by ionizing radiation, and it seems to be clear that this process involves di€erent mitogen activated protein (MAP) kinases, dependent on the speci®c cell type examined. However, early steps leading to activation of the corresponding pathways and thus to overexpression of Egr-1 are not well understood.

10p research12 29-04-2013 29 1   Download

Ephrin receptor tyrosine kinase A3 (EphA3, EC 2.7.10.1) is a member of a unique branch of the kinome in which downstream signaling occurs in both ligand- and receptor-expressing cells. Consequently, the ephrins and ephrin receptor tyrosine kinases often mediate processes involving cell–cell con-tact, including cellular adhesion or repulsion, developmental remodeling and neuronal mapping.

10p vinaphone15 25-02-2013 21 2   Download

mRNA stabilization plays an important role in the changes in protein expression initiated by inducers of inflammation or direct cell stress such as UV light. This study provides evidence that stabilization in response to UV light differs from that induced by proinflammatory stimuli such as bacterial lipopolysaccharide or interleukin (IL)-1. Firstly, UV-induced stabilization is independent of the p38 MAP kinase pathway, which has previously been shown to medi-ate stabilization induced by IL-1 or lipopolysaccharide....

10p tumor12 22-04-2013 30 1   Download