Molecules with more than

The ability of aminoacyl-tRNA synthetases to distinguish betweensimilaraminoacidsiscrucial foraccuratetrans-lation of the genetic code. Saccharomyces cerevisiae seryl-tRNA synthetase (SerRS) employs tRNA-dependent recognition of its cognate amino acid serine [Lenhard, B., Filipic, S., Landeka, I., Skrtic, I., So¨ll, D. & Weygand-Durasevic, I. (1997)J. Biol. Chem.272, 1136–1141]. Herewe show that dimeric SerRS enzyme complexed with one molecule of tRNA Ser is more specific and more efficient in catalyzing seryl-adenylate formation than the apoenzyme alone. ...

9p tumor12 22-04-2013 38 2   Download

14-3-3 proteins belong to a family of conserved molecules expressed in all eukaryotic cells, which play an important role in a multitude of signaling pathways. 14-3-3 proteins bind to phosphoserine⁄phosphothreonine motifs in a sequence-specific manner. More than 200 14-3-3 binding partners have been found that are involved in cell cycle regulation, apoptosis, stress responses, cell metabolism and malignant transformation.

9p dell39 27-03-2013 43 3   Download