Multidrug resistance

There is a return of colistin as the treatment of last resort for multi-resistant bacteria. However, due to the limited penetration in the lung parenchyma and the renal side effects, the effectiveness of intravenous (IV) colistin therapy has been questioned. Colistin inhalation therapy is deemed tolerable, safe, and could be a beneficial therapy.

10p vibecca 01-10-2024 0 0   Download

Staphylococcus aureus is a major problem in both the clinical setting and within the community. S. aureus can quickly develop resistance to a wide range of antibiotics through a number of different mechanisms, of which, using transporters located in the cell membrane to pump antibiotics out of the cell is the most serious concern.

8p vibecca 01-10-2024 4 2   Download

This study raises a warning about the circulation and dissemination of VRSA in Vietnam. The key proteins would be potential targets for the development of anti-virulent agents to combat the VRSA infection.

14p viling 27-09-2024 3 2   Download

New antimicrobials are urgently needed to combat the threat of multidrug-resistant bacteria worldwide. Our study aimed to access the antimicrobial and cytotoxic profiles of endophytic actinomycetes associated with Cinnamomum cassia Presl taken from a mountainous region in the Northwest of Vietnam.

11p viling 27-09-2024 4 2   Download

In conclusion, sequence analysis may be useful for the rapid detection of STR resistance in MDR M. tuberculosis strains, which in turn could contribute to better control strategies of TB in Vietnam. Other molecular mechanisms associated with STR resistance in STR-resistant strains without mutations in the rpsL and rrs genes need to be further investigated.

11p dianmotminh02 03-05-2024 4 1   Download

RNA cargo in exosomes, especially microRNAs (miRNAs), play an important role in the chemotherapy drug resistance of human cancers. However, the role and mechanism of exosomal miR-107 on multidrug resistance of gastric cancer cells was still not clear. In this study, we sought to explore whether exosomal miR-107 could reverse the resistance of gastric cancer cells to the chemotherapy drugs.

16p vielonmusk 21-01-2022 13 0   Download

Higher resistance was observed in food samples than in clinical ones. Moreover, 13 and 3 multidrug resistant serotypes of Salmonella were identified for the first time in Lebanon in the food and clinical samples respectively, with three of them isolated from imported food samples.

5p mudbound 10-12-2021 9 1   Download

The objectives of the thesis: Identify Salmonella isolated from pork, beef, and chicken meat at the retail markets in Hanoi. Determining antibiotic resistance characteristics of isolated Salmonella.

26p extraenglish 24-05-2021 31 3   Download

The objectives of the thesis: Identify Salmonella isolated from pork, beef, and chicken meat at the retail markets in Hanoi; determining antibiotic resistance characteristics of isolated Salmonella; analysis of related gene categories in multi-antibiotic resistant Salmonella.

26p larachdumlanat129 20-01-2021 17 5   Download

India accounts for 30% of neonatal deaths globally. Bacterial sepsis is a significant cause of morbidity and mortality in newborns. The study helps to make antibiotic policy in neonatal sepsis. The main objective is to study the incidence of multidrug resistant gram negative and gram positive organisms causing neonatal septicemia and their antibiotic sensitivity pattern. The study was conducted in the Department of Microbiology over a period of one year. Sample of blood was collected under aseptic precautions and processed by standard techniques.

5p gaocaolon5 14-06-2020 24 3   Download

Trong đề tài này, mô hình mô tả phân tử docking được xây dựng nhằm xác định tương tác của các chất ức chế với các acid amin tại khoang trung tâm và dự đoán các chất có khả năng ức chế hoạt tính bơm. Công cụ FlexX tích hợp trong LeadIT được sử dụng để nghiên cứu mô hình mô tả phân tử docking của 204 chất có hoạt tính ức chế bơm.

4p vihercules2711 26-03-2019 55 2   Download

P-glycoprotein (Pgp), a membrane pump often responsible for the multidrug resistance of cancer cells, undergoes conformational changes in the presence of substrates/modulators, or upon ATP depletion, reflected by its enhanced reactivity with the UIC2 monoclonal antibody. When the UIC2-shift was elicited by certain modulators (e.g. cyclosporin A or vinblastine, but not with verapamil or Tween 80), the subsequent binding of other monoclonal anti-Pgp Ig sharing epitopes with UIC2 (e.g. MM12.10) was abolished [Nagy, H., Goda, K., Arceci, R., Cianfriglia, M., ´ Mechetner, E. & Szabo Jr, G.

6p system191 01-06-2013 62 7   Download

The human multidrug resistance-associated protein (MRP1) is an ATP-dependent efflux pump that transports anionic conjugates, and hydrophobic compounds in a glutathione dependent manner. Similar to the other, well-characterized multidrug transporter P-gp, MRP1 comprises two nucleotide-binding domains (NBDs) in addition to transmembrane domains. However, whereas the NBDs of P-gp have been shown to be functionally equivalent, those of MRP1 differ significantly.

9p research12 01-06-2013 25 4   Download

The human multidrug resistance protein 2 (MRP2, symbol ABCC2) is a polytopic membrane glycoprotein of 1545 amino acids which exports anionic conjugates across the apical membrane of polarized cells. A chimeric protein composed of C-proximal MRP2 and N-proximal MRP1 localized to the apicalmembraneof polarizedMadin±Darby canine kidney cells (MDCKII) indicating involvement of the carboxy-proximal part of human MRP2 in apical sorting.

11p research12 23-04-2013 31 2   Download

The nature of cGMP transport in human erythrocytes, its relationship to glutathione conjugate transport, and pos-sible mediation by multidrug resistance-associated proteins (MRPs) have been investigated. MRP1, MRP4 and MRP5 are detected in immunoblotting studies with erythrocytes. MRP1and MRP5 are also detected in multidrug resistant COR-L23/R and MOR/R cells but at greatly reduced levels in the parent, drug sensitive COR-L23/P cells. MRP4 is detected in MOR/R but not COR-L23/R cells.

13p tumor12 20-04-2013 41 3   Download

Multidrug resistance (MDR) in tumour cells is often caused by the overexpression of the plasma drug transporter P-glycoprotein (P-gp). This protein is an active efflux pump for chemotherapeutic drugs,natural products and hydro-phobicpeptides.Despite theadvancesof recent years,we still have an unclear view of the molecular mechanismby which P-gp transports such a wide diversity of compounds across themembrane.

10p tumor12 20-04-2013 42 4   Download

P-glycoprotein (Pgp), a member of the ATP-binding cassette (ABC) super-family responsible for the ATP-driven extrusion of diverse hydrophobic molecules from cells, is a cause of multidrug resistance in human tumours. Pgp can also operate as a phospholipid and glycosphingolipid flippase, and has been functionally linked to cholesterol, suggesting that it might be associated with sphingolipid–cholesterol microdomains in cell membranes.

14p fptmusic 12-04-2013 30 3   Download

Plant flavonoids are polyphenolic compounds, commonly found in vegeta-bles, fruits and many food sources that form a significant portion of our diet. These compounds have been shown to interact with several ATP-bind-ing cassette transporters that are linked with anticancer and antiviral drug resistance and, as such, may be beneficial in modulating drug resistance. This study investigates the interactions of six common polyphenols; querce-tin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. ...

16p fptmusic 12-04-2013 40 2   Download

Sanguinarine has been shown to inhibit proliferation of several types of human cancer cell including multidrug-resistant cells, whereas it has min-imal cytotoxicity against normal cells such as neutrophils and keratino-cytes. By analyzing the antiproliferative activity of sanguinarine in relation to its effects on mitosis and microtubule assembly, we found that it inhibits cancer cell proliferation by a novel mechanism.

12p inspiron33 26-03-2013 41 3   Download

The multidrug resistance-associated protein transporter ABCC1 (MRP1) is an integral plasma membrane protein involved in the multidrug resistance phenotype. It actively expels a number of cytotoxic molecules from cells. To gain insight into the modulation of the functional properties of this integral membrane protein by cholesterol, a main component of the lipid bilayer, we used multidrug-resistant GLC4⁄ADR cells,

11p galaxyss3 21-03-2013 44 5   Download