Nitric oxide system

The discovery that nitric oxide (NO) plays crucial roles in mammalian systems has spurred considerable interest in its translational application. However, the major problem with its application in clinical settings is the high reactivity of NO, which makes it difficult to supply NO with spatiotemporal accuracy while maintaining its bioactivity.

11p sony2711 28-01-2019 13 0   Download

Nitric oxide synthases belong to a family of dual-flavin enzymes that trans-fer electrons from NAD(P)H to a variety of heme protein acceptors. Dur-ing catalysis, their FMN subdomain plays a central role by acting as both an electron acceptor (receiving electrons from FAD) and an electron donor, and is thought to undergo large conformational movements and engage in two distinct protein–protein interactions in the process.

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Endotoxin molecules in lipopolysaccharides are among most important molecules that initiate a cascade of events in sepsis/ endotoxemia. Lipopolysaccharide exposure may result in strong immune responses, disrupt the intracellular oxidant/antioxidant balance, and cause excessive reactive oxygen species generation.

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This study investigated the correlation between endogenous levels of some signal compounds [nitric oxide (NO), salicylic acid (SA), abscisic acid (ABA)] and the antioxidant system in response to chilling stress in maize (Zea mays L.). The results showed that chilling stress caused oxidative damage, and changes in signal molecules (NO, SA, and ABA) and NR activity in maize.

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus...

6p thulanh16 21-10-2011 35 3   Download

Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans.

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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis

4p hoami_266 15-09-2011 29 2   Download

part 2 book “medicinal plants in asia for metabolic syndrome - natural products and molecular basis” has contents: inhibiting insulin resistance and accumulation of triglycerides and cholesterol in the liver, increasing the sensitivity of adipocytes and skeletal muscle cells to insulin, inhibiting low-density lipoproteins intimal deposition and preserving nitric oxide function in the vascular system.

312p tieu_vu14 15-08-2018 14 0   Download

In the synthesis of ammonia, under industrial conditions, the reaction normally comes sufficiently close to equilibrium for the applications of thermodynamics to prove of immense value. t Thus it will predict the influence of changes of pressure, temperature and composition on the maximum attainable yield. By contrast in the catalytic oxidation of ammonia the yield of nitric oxide is determined, not by the opposition of forward and backward reactions, as in ammonia synthesis, but by the relative speeds of two independent processes which compete with each other for the available ammonia.

0p thienbinh1311 13-12-2012 28 2   Download

The results of the present study show that human platelets take up L-arginine by two transport systems which are compatible with the systems y + and y + L. These Na + -independent transporters have been distinguished by treat-ing platelets with N-ethylmaleimide that blocks selectively systemy + .Systemy + , that accounts for 30–40%of the total transport, is characterized by low affinity forL-arginine, is unaffected byL-leucine, is sensitive to changes of membrane potential and totrans-stimulation. ...

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Nitric oxide (NO) is a potent intra- and intercellular mes-senger involved in the control of vascular tone, neuronal signallingandhost response to infection. Inmammals,NOis synthesized by oxidation ofL-arginine catalysed by heme-proteins called NO-synthases with intermediate formation of N x -hydroxy-L-arginine (NOHA). NOHA and some hydroxyguanidines have been shown to be able to deliver nitrogen oxides including NO in the presence of various oxidative systems.

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Platelets are sensitive cells and are easily activated by different stimulants in the circulation system. It is known that tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine and plays a role in inflammation. The role of TNF-α in the apoptotic process in blood platelets is unknown.

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The dynamics of gas release at thermal oxidation of extraction systems on the basis of diamides of dicarbonic acids in fluorinated sulphones with 14 mol/L HNO3 was investigated. The effect of preirradiation of the mixtures with accelerated electrons on the kinetics of their thermolysis was determined.

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Secondary aerosol is produced by the oxidation of primary gases (sulphur dioxide, SO2, nitrogen oxides, NOx, and volatile organic compounds, VOCs,) to sulphuric and nitric acid, and organic vapours, followed by their gas-particle conversion [26, 77]. Finally, some of these acidic gases can be neutralised by reaction with ammonia gas or calcium carbonate (calcite) forming secondary aerosol (ammonium sulphate, ammonium nitrate, calcium sulphate, calcium nitrate).

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Neural Control The small intestine and colon have intrinsic and extrinsic innervation. The intrinsic innervation, also called the enteric nervous system, comprises myenteric, submucosal, and mucosal neuronal layers. The function of these layers is modulated by interneurons through the actions of neurotransmitter amines or peptides, including acetylcholine, vasoactive intestinal peptide (VIP), opioids, norepinephrine, serotonin, ATP, and nitric oxide. The myenteric plexus regulates smooth-muscle function, and the submucosal plexus affects secretion, absorption, and mucosal blood flow.

5p ongxaemnumber1 29-11-2010 65 4   Download