Nitric oxide system

Nitric oxide (NO) is a potent intra- and intercellular mes-senger involved in the control of vascular tone, neuronal signallingandhost response to infection. Inmammals,NOis synthesized by oxidation ofL-arginine catalysed by heme-proteins called NO-synthases with intermediate formation of N x -hydroxy-L-arginine (NOHA). NOHA and some hydroxyguanidines have been shown to be able to deliver nitrogen oxides including NO in the presence of various oxidative systems.

9p tumor12 20-04-2013 40 4   Download

The results of the present study show that human platelets take up L-arginine by two transport systems which are compatible with the systems y + and y + L. These Na + -independent transporters have been distinguished by treat-ing platelets with N-ethylmaleimide that blocks selectively systemy + .Systemy + , that accounts for 30–40%of the total transport, is characterized by low affinity forL-arginine, is unaffected byL-leucine, is sensitive to changes of membrane potential and totrans-stimulation. ...

8p fptmusic 16-04-2013 40 3   Download

Nitric oxide synthases belong to a family of dual-flavin enzymes that trans-fer electrons from NAD(P)H to a variety of heme protein acceptors. Dur-ing catalysis, their FMN subdomain plays a central role by acting as both an electron acceptor (receiving electrons from FAD) and an electron donor, and is thought to undergo large conformational movements and engage in two distinct protein–protein interactions in the process.

16p vinaphone15 25-02-2013 28 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus...

6p thulanh16 21-10-2011 52 4   Download

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis

4p hoami_266 15-09-2011 39 4   Download