Pancreatic and gastric cancer

To gain better insight into the insulin secretory activity of fetalbcells in response to glucose, the expression of glucose transporter 2 (GLUT-2), glucokinase and mitochondrial glycerol phosphate dehydrogenase (mGDH) were studied. Expression ofGLUT-2mRNA and protein in pancreatic islets and liver was signi®cantly lower in fetal and suckling rats than in adult rats.

9p research12 29-04-2013 47 4   Download

We purified pancreatic deoxyribonucleases I (DNases I) from three snakes, Elaphe quadrivirgata, Elaphe climaco-phoraandAgkistrodon blomhoffii, and cloned their cDNAs. Each mature snake DNase I protein comprised 262 amino acids. Wild-type snake DNases I with Leu130 were more thermally unstable than wild-type mammalian and avian DNases I with Ile130. After substitution of Leu130Ile, the thermal stabilities of the snake enzymes were higher than those of their wild-type counterparts and similar to mam-malian wild-type enzyme levels....

8p tumor12 20-04-2013 41 3   Download

Chromosomal rearrangements apparently account for the presence of a pri-mate-specific gene (protease serine 3) in chromosome 9. This gene encodes, as the result of alternative splicing, both mesotrypsinogen and trypsino-gen 4. Whereas mesotrypsinogen is known to be a pancreatic protease, neither the chemical nature nor biological function of trypsinogen 4 has been explored previously.

11p galaxyss3 21-03-2013 41 3   Download