Pathogenesis

Cytokines play an essential role in the pathogenesis related to the severity, monitor progress, and evaluate ICS therapeutic response in asthma. Research objectives: Evaluate changes in serum levels of IL4, IL5, IL13, and TNFα in patients with asthma control according to GINA after 3 months.

9p viengfa 28-10-2024 2 1   Download

Chronic pancreatitis (CP) is a benign inflammatory disease involving the progressive and irreversible destruction of the pancreatic tissue, fibrosis and loss of exocrine and endocrine function. Clinical management of CP is also challenging because of the incomplete understanding of disease and pain pathogenesis. In Hue Central Hospital, CP is primarily treated with open drainage procedures.

7p vinatisu 29-08-2024 2 1   Download

Congenital abnormalities of the kidney and urinary tract are common. In particular, the duplicated collecting system is one of the most common kidney abnormalities, but most are asymptomatic. The pathogenesis of these abnormalities is also known very little and some pathogenic genes are thought to be related.

5p vinatisu 29-08-2024 2 1   Download

Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age. Insulin resistance appears to be a critical factor in PCOS pathogenesis. Metformin, an insulin-sensitizing agent, is thus the preferred treatment option for PCOS.

8p vinatisu 29-08-2024 3 1   Download

Stomach adenocarcinoma (STAD), which accounts for approximately 95% of gastric cancer types, is a malignancy cancer with high morbidity and mortality. Tumor angiogenesis plays important roles in the progression and pathogenesis of STAD, in which long noncoding RNAs (lncRNAs) have been verified to be crucial for angiogenesis.

14p vielonmusk 21-01-2022 10 0   Download

To investigate biological roles of Myosin class I in the morphology of M. circinelloides and identify good candidates for further analyses of Mucor pathogenesis, we are going to inhibit their expression using RNAi technique. We named the two myosin class I like genes as M1L1 (ID 140500) and M1L2 (ID 116620). In the present study, we report the results of generation of RNAi plasmid to inhibit the expression of M1L1 gene.

6p koxih_kothogmih5 04-09-2020 39 3   Download

Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. c the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection.

8p kethamoi1 17-11-2019 29 2   Download

LTP (Lipid Transfer Protein) thuộc họ gen pathogenesis relate, đƣợc xác định có liên quan với khả năng chịu hạn ở thực vật. Trong nghiên cứu này chúng tôi trình bày kết quả so sánh khả năng chịu hạn và phân lập gen LTP liên quan đến khả năng chịu hạn ở giống đậu xanh 044/ĐX06 và HN2.

7p cumeo2425 02-07-2018 82 3   Download

Document "Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis" presentation of content: Epidemiology, pathogenesis and risk factors, diagnosis, management, summary, references.

29p vovanvovan2013 13-05-2016 68 2   Download

Document presentation of content: Epidemiology and transmission of hepatitis B, pathogenesis and natural history, laboratory diagnosis of hepatitis B, long-term monitoring and screening of chronic hepatitis B, treatment for chronic hepatitis B, hepatitis B vaccination, automatic searches, guidelines, further reading, and web sites.

29p vovanvovan2013 13-05-2016 47 1   Download

Document "Constipation: A global perspective" introduction of content: Cascades—a resource-sensitive approach, pathogenesis and risk factors, associated conditions and medication, diagnostic criteria for functional constipation, patient evaluation,... Invite you to consult.

13p vovanvovan2013 13-05-2016 35 2   Download

In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high affinity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was significantly enhanced by Zn2+, an effect possibly mediated through Cys-rich zinc finger-like sequences on laminin....

8p system191 01-06-2013 41 4   Download

The immune coagulant fgl2/fibroleukin has been previously shown to play a pivotal role in the pathogenesis of murine and human fulminant hepatitis and fetal loss syndrome. Constitutive expression of fgl2 transcripts at low levels are seen in cytotoxic T cells, endothelial, intestinal and tropho-blast cells, while specific factors (such as virus and cytokines) are required to induce high levels of fgl2 expression in other cell types including monocytes/macrophages.

13p fptmusic 16-04-2013 37 5   Download

Flexibacter maritimus, a Gram-negative bacterium, is a fish pathogenresponsible fordisease infinfishspecies andacause of cutaneous erosiondisease in sea-caged salmonids. For the development of serology based diagnostics, protective vac-cines, and a study of pathogenesis, the structural analysis of the lipopolysaccharide (LPS) producedby the bacteriumhas been undertaken. We now report that an acidic O-specific polysaccharide, obtained by mild acid degradation of the F. maritimusLPSwas found to be composed of a disac-...

6p fptmusic 16-04-2013 45 3   Download

The Goodpasture antigen-binding protein, GPBP, is a serine⁄threonine kinase whose relative expression increases in autoimmune processes. Tumor necrosis factor (TNF) is a pro-inflammatory cytokine implicated in auto-immune pathogenesis. Here we show that COL4A3BP, the gene encoding GPBP, maps head-to-head withPOLK, the gene encoding for DNA polymerase kappa (polj), and shares with it a 140-bp promoter containing a Sp1 site, a TATA-like element, and a nuclear factor kappa B (NFjB)-like site

15p fptmusic 12-04-2013 36 3   Download

Tobacco pathogenesis-related protein 1a (PR-1a) is induced in plants during the hypersensitive response (HR) after exposure of plants to salicylic acid (SA) and by develop-mental cues.Gene activation by these diverse stimuli is mediated via anas-1-like element in the PR-1aupstream region.To further analyze the significance of thiscis-acting sequence, an authentic as-1element from the cauliflower mosaic virus 35S RNA promoter was inserted into the PR-1apromoter in place of theas-1-like motif.

11p fptmusic 12-04-2013 35 3   Download

The pathogenesis of formation of neurofibrillary tangles (NFTs) in Alzhei-mer’s disease (AD) brains is unknown. One of the possibilities might be that translation of tau mRNA is aberrantly regulated in AD brains.

10p fptmusic 11-04-2013 58 3   Download

Fibrillization ofa-synuclein (a-Syn) is closely associated with the formation of Lewy bodies in neurons and dopamine (DA) is a potent inhibitor for the process, which is implicated in the causative pathogenesis of Parkin-son’s disease (PD). To elucidate any molecular mechanism that may have biological relevance, we tested the inhibitory abilities of DA and several analogs including chemically synthetic and natural polyphenols in vitro.

12p fptmusic 11-04-2013 43 2   Download

Recently, a novel plaque-associated protein, collagenous Alzheimer amy-loid plaque component (CLAC), was identified in brains from patients with Alzheimer’s disease. CLAC is derived from a type II transmembrane colla-gen precursor protein, termed CLAC-P (collagen XXV). The biological function and the contribution of CLAC to the pathogenesis of Alzheimer’s disease and plaque formation are unknown.

0p awards 06-04-2013 27 2   Download

Oxidative stress and imbalance between free radical generation and detoxi-fication may play a pivotal role in the pathogenesis of Leber’s hereditary optic neuropathy (LHON). Mitochondria, carrying the homoplasmic 11778⁄ND4, 3460⁄ND1 and 14484⁄ND6 mtDNA point mutations associ-ated with LHON, were used to generate osteosarcoma-derived cybrids. Enhanced mitochondrial production of reactive oxygen species has recently been demonstrated in these cybrids [Beretta S, Mattavelli L, Sala G, Trem-olizzo L, Schapira AHV, Martinuzzi A, Carelli V & Ferrarese C (2004) Brain127, 2183–2192]. ...

0p awards 05-04-2013 44 4   Download