Progesterone receptor

Gprotein-coupled receptor 30 (GPR30) has previously been described tobe important in steroid-mediatedgrowthand to inhibit cell proliferation. Here we investigated whether the effect of GPR30 on cell growth is dependent on steroid hormone receptors. We stably introduced GPR30 in immortalizednormalmammaryepithelial (HME) cellsusing retroviruses for gene delivery. GPR30 inhibited the growth and proliferation of the cells. They expressed glucocorticoid receptor, but not estrogen or progesterone receptor....

10p awards 05-04-2013 49 6   Download

Transcriptional control of the progesterone receptor gene by estrogen is a complex mechanism. It involves estrogen receptora which uses several enzymes that locally modify histone tails as cofactors. Using MCF-7 cells as a model, we found that Jumonji AT-rich interactive domain 1A (JARID1A; KDM5A⁄RBP2), an enzyme that removes the activating H3K4 di- and trimethylation marks, was involved in the fine-tuning of pro-gesterone receptor gene expression.

12p cosis54 05-01-2013 25 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Progesterone receptor does not improve the performance and test effectiveness of the conventional 3-marker panel, consisting of estrogen receptor, vimentin and carcinoembryonic antigen in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray extension study

9p dauphong3 03-01-2012 40 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance

5p panasonic01 12-12-2011 56 4   Download

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares...

8p coxanh_1 22-10-2011 50 4   Download

Patients with stage IV disease (outside the abdomen or invading the bladder or rectum) are treated palliatively with irradiation, surgery, and platinum-based chemotherapy. Progestational agents produce responses in ~10–20% of patients. Well-differentiated tumors respond most frequently, and response can be correlated with the level of progesterone receptor expression in the tumor.

5p konheokonmummim 03-12-2010 90 4   Download

Endocrine Therapy Normal breast tissue is estrogen-dependent. Both primary and metastatic breast cancer may retain this phenotype. The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor. Tumors that are positive for the estrogen receptor and negative for the progesterone receptor have a response rate of ~30%. Tumors that have both receptors have a response rate approaching 70%. If neither receptor is present, the objective response rates are ...

5p konheokonmummim 03-12-2010 82 4   Download

Table 86-2 5-Year Survival Rate for Breast Cancer by Stage Stage 5-Year Survival, % 0 99 I 92 IIA 82 IIB 65 IIIA 47 IIIB 44 IV 14 Source: Modified from data of the National Cancer Institute—Surveillance, Epidemiology, and End Results (SEER). Estrogen and progesterone receptor status are of prognostic significance. Tumors that lack either or both of these receptors are more likely to recur than tumors that have them. Several measures of tumor growth rate correlate with early relapse. S-phase analysis using flow cytometry is the most accurate measure.

5p konheokonmummim 03-12-2010 76 3   Download

Thuốc kháng progestin Mifepriston Được dùng đầu tiên ở Pháp vào năm 1988 Mifepriston là dẫn xuất của 19 - norprogestin, gắn mạnh vào receptor của progesteron. Nếu có mặt progestin, mifepriston tác dụng như một chất đối kháng tranh chấp tại receptor, nếu tác dụng một mình thì mifepriston lại có tác dụng như progestin, nhưng yếu (đồng vận một phần - partial agonist) Dùng vào giai đoạn sớm của thai kỳ, mifepriston làm bong màng rụng do phong tỏa các receptor progesteron của tử cung, dẫn đến bong túi mầm (blastocyst), làm giảm sản xuất choriogonadotropin (CG). Chính những tác...

5p super_doctor 25-10-2010 283 7   Download