Systems immunology

This compassionate guide explains how hepatitis C affects the liver and the body and provides solid advice on today's treatment options-from drugs (and their side effects) to transplants and alternative therapies-as well as tips on dealing with the emotional and financial burdens the disease brings with it. Nina L Paul, PhD (New York, NY) earned her doctorate in infectious disease epidemiology and immunology from Yale University. She has researched viruses (human immunodeficiency virus and others) and the immune system.

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Different from other resources, this volume offers a broad appeal to microbiologists, immunologists, and infectious disease specialists on Autoimmune Diseases. The volume covers topics such as skin and alopecia, Kidney, Liver, Paraneoplastic, Resolution of inflammation, Cardiovascular/systemic inflammation and atherosclerosis, Gut, Regulatory lymphocytes T, B, other and Rheumatic Disease. The volume is written by internationally renowned authors who are authorities in their respective fields.

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Part 2 book "A textbook of opthalmology" includes content: Ocular diseases and ocular affections in systemic diseases - urgical procedures, miscellaneous aspects, genetics and paediatric ophthalmology, immunology related to ocular disorders, prevention and rehabilitation of blindness.

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Ebook "Immunoformatics: Bioinformatic strategies for better understanding of immune function" is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data.

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Ebook "Mathematical models and immune cell biology" contains chapters on mathematical modelling, on immunology, and on mathematical modelling in immunology. Although there is a bias towards the adaptive immune system, and towards T cells in particular, the reader will find Chapters on dendritic cells, B cells and germinal centres.

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Ebook "Eco-immunology: Evolutive aspects and future perspectives" represents a cutting-edge contribution giving an all-around perspective of eco-immunology today. Beside questions of the utmost importance for the whole community of immunologists, e.g, the intrinsic limits of immunological experiments performed at the bench on a limited number of selected models, the book covers several other facets of the eco-immunological approach, including host-parasite interactions, human aging and population immunology.

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There are fundamental differences between humans and the animals we typically use to study the immune system. We have learned much from genetically manipulated and inbred animal models, but instances in which these findings have been successfully translated to human immunity have been rare.

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Systems immunology has the potential to offer invaluable insights into the development of the immune system. Two recent studies offer an in-depth view of both the dynamics of immune system development and the heritability of the levels of key immune modulators at birth.

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There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development.

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The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear.

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Part 2 book "2013 CURRENT medical diagnosis and treatment" includes content: Blood disorders; disorders of hemostasis, thrombosis and antithrombotic therapy; gastrointestinal disorders; liver, biliary tract and pancreas disorders; breast disorders; gynecologic disorders; obstetrics and obstetric disorders; musculoskeletal and immunologic disorders; electrolyte and acid base disorders; kidney disease; urologic disorders; nervous system disorders; psychiatric disorders; endocrine disorders; diabetes mellitus and hypoglycemia; lipid disorders.

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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.

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Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection.

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Part 2 book "Medical terminology - A programmed systems approach" includes content: Neurology, psychology, anesthesiology, and vascular terminology; anatomic terms; surgery, diabetes, immunology, lesions,and prefixes of numbers and direction; descriptive prefixes, asepsis, and pharmacology; prefixes of location and medication administration; respiratory system and pulmonology; word parts for night, sleep, split, skeletal system, and orthopedics; ophthalmology, endocrinology, and medical specialties.

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Being expressed in all stages of B-cell development and having a significant value on the European Group for the Immunological Characterization of Acute Leukemias scoring system, CD79a is considered as an excellent pan-marker for lineage assignment of B cells by flow cytometry.

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Clopidogrel and ticagrelor are rarely reported to cause vasculitis via drug hypersensitivity reaction, largely mediated by T cells and immunoglobulin E (IgE). Despite therapeutic advances, the etiology of refractory vasculitides remains incompletely understood. Recently, (non)immunological mechanisms bypassing T cells and IgE have been proposed to explain resistance to standard immunosuppressants.

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Polyagglutinability of red blood cells is a rare immunological phenomenon, it is due to a cryptic antigen that is abnormally present on the surface of red blood cells. The aim of our work is to shed light on polyagglutinability, which is still poorly understood cause of discordance between the cell and serum tests and can sometimes have harmful transfusion consequences.

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Part 2 book "Ferret medicine and surgery" includes content: Disorders of the haemic, immunological and lymphatic systems; disorders of the musculoskeletal system; disorders of the nervous system; disorders of the oral cavity and teeth; disorders of the respiratory system; disorders of the skin; disorders of the urogenital system; miscellaneous conditions; analgesia and anaesthesia; common surgical procedures; paediatrics; geriatrics; rescue centre medicine; toxicology; formulary.

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Part 1 book "Veterinary immunology" includes content: Surviving in a microbial world; innate immunity; humoral innate immunity; humoral innate immunity; cellular innate immunity; cellular innate immunity; sickness; how immune cells communicate; antigens; dendritic cells and antigen processing; the major histocompatibility complex; organs of the immune system; lymphocytes; helper t-cells and their response to antigens; b-cells and their response to antigens; antibodies.

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Part 2 book "Veterinary immunology" includes content: How antigen binding receptors are made; t-cells and the destruction of cell associated invaders; innate lymphoid cells; regulation of adaptive immunity; the microbiota and the immune system; immunity at body surfaces; immunity in the fetus and newborn; vaccines and their production; the use of vaccines; immunity to bacteria and fungi; immunity to viruses; immunity to parasites,... and other contents.

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