Targeted drug delivery

Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved.

12p vikoch 27-06-2024 1 1   Download

Part 2 book "Fundamentals and applications of controlled release drug delivery" includes content: Targeted delivery using biodegradable polymeric nanoparticles; liposomes in drug delivery; receptor mediated delivery systems for cancer therapeutics, biological rhythms, drug delivery, and chronotherapeutics; site specific controlled release for cardiovascular disease - translational directions; drug delivery systems to fight cancer; fundamentals of vaccine delivery in infectious diseases; tissue engineering in drug delivery.

340p muasambanhan10 03-04-2024 1 0   Download

Ebook "Nanoparticles in lung cancer therapy - Recent trends" provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients.

78p tudohanhtau1006 29-03-2024 6 1   Download

Ebook "The blood brain barrier (BBB)" covers all relevant aspects of drug research, e.g.

169p nhanphanguyet 28-01-2024 5 2   Download

Ebook "Drug target miRNA: Methods and protocols" provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters.

318p lucchinguyen 28-12-2023 3 2   Download

Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and targeting moieties could improve the therapeutic delivery of anti-cancer drugs.

14p vileonardodavinci 23-12-2023 4 3   Download

Part 2 book How to overcome the antibiotic crisis - Facts, challenges, Technologies and future perspectives" includes content: History of antibiotics research, exploitation of fungal biodiversity for discovery of novel antibiotics; new structural templates for clinically validated and novel targets in antimicrobial drug research and development, synthesis of antibiotics, antibiotics clinical development and pipeline..... and other contents.

286p oursky06 17-10-2023 5 2   Download

The dense stroma of pancreatic ductal adenocarcinomas is a major barrier to drug delivery. To increase the local drug difusion gradient, high doses of chemotherapeutic agent doxorubicin can be released from thermally-sensitive liposomes (ThermoDox®) using ultrasound-mediated hyperthermia at the tumour target.

10p vioracle 29-09-2023 7 3   Download

Tissue engineering has garnered considerable attention within the broader field of regenerative medicine that utilizes naturally-occurring nanomaterials as fillers in polymeric scaffolds and as carriers for sustained, targeted drug delivery. These nanomaterials act as functional constructs for the recovery of defective tissues and organs, which may aid in overcoming the current challenges of donor organ shortage.

14p viberbers 09-08-2023 5 4   Download

Polyphyllin I (PPI) is a naturally active steroidal saponin that has good therapeutic effects in various cancers, such as liver and lung cancers. However, owing to its non-selective distribution in various tissues, it is toxic and has side effects on normal human organs while taking effect.

12p viberbers 09-08-2023 3 2   Download

In the diagnosis and treatment of cancer, the nano drug delivery systems have been intensively researched for many years because they are capable of concentrating drugs at the target for a longer time, while protecting other tissues in the body.

10p vidudley 20-02-2023 6 2   Download

Melanoma is the most aggressive type of skin cancer with high rates of mortality. Despite encouraging advances demonstrated by anticancer drug carriers in recent years, developing ideal drug delivery systems to target tumor microenvironment by overcoming physiological barriers and chemotherapy side effects still remain intimidating challenges.

12p vihermione 06-01-2023 3 2   Download

Micelles are one of the most investigated nanocarriers for drug delivery. In this study, polymeric micelles based on chitosan were prepared to explore the delivery mechanism which was critical for enhancing tumor targeting but still remain elusive.

9p vihermione 06-01-2023 7 2   Download

Although the field of oncology nanomedicine has shown indisputable progress in recent years, cancer remains one of the most lethal diseases, where the early diagnosis plays a pivotal role in the patient's prognosis and therapy.

14p viginny 30-12-2022 11 2   Download

Targeted colonic drug delivery systems are needed for the treatment of endemic colorectal pathologies, such as Crohn’s disease, ulcerative colitis, and colorectal cancer. These drug delivery vehicles are difficult to formulate, as they need to remain structurally intact whilst navigating a wide range of physiological conditions across the upper gastrointestinal tract.

11p viginny 30-12-2022 7 2   Download

Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen threedimensional network of synthetic polymers or natural macromolecules such as polysaccharides.

17p viginny 30-12-2022 8 2   Download

Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and destructive side effects. For this purpose, magnetic generation 4 dendrimeric nanoparticles were prepared to carry chemotherapeutic agent doxorubicin (G4 -DOX) and immune modulator polyinosinic:polycytidylic acid [Poly(I:C)]. As previously reported, DOX and Poly(I:C) was loaded onto G4 nanoparticles (PIC-G4 -DOX).

12p thiencuuchu 27-11-2021 4 1   Download

The concept of personalized therapy has been proven to be a promising approach. A popular technique is to utilize gold nanoparticles (AuNPs) as drug delivery vectors for cytotoxic drugs and small molecule inhibitors to target and eradicate oral cancer cells in vitro and in vivo.

16p vianrose2711 27-04-2021 11 2   Download

Understanding the binding mechanism between gold nanoparticles and biomolecules is a fundamental step for numerous applications in biosensors and targeted drug delivery. This study aims to clarify the adsorption behaviors of CYS and GSH on the gold surface using a small gold Au8 cluster as a model reactant.

9p larachdumlanat127 02-01-2021 11 2   Download

Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine have led to the use of tumour xenografts in testing nanoscale delivery devices, such as nanoparticles and polymer-drug conjugates, for targeting and efficacy via the enhanced permeability and retention (EPR) effect.

10p vijisoo2711 30-09-2020 10 1   Download