Mammalian G1 phase progression is regulated by G1 cyclin and cyclin-dependent kinases (cdks). Cdk4 or cdk6 is associated with D-type cyclins while cdk2 binds to cyclin E or cyclin A to become an independent and essential kinase [1,2]. Cdk3 is another putative G1 cdk, whose cyclin partners have not been identified [3]. In vitro, cdk3 is an active kinase in association with either cyclin E or cyclin A [4,5]. In eukaryotes, overexpression of a dominant-negative cdk3 induces G1 arrest, which is not rescued by upregulation of wild-type cdk2, suggesting that the function of cdk3 is distinct from that of cdk2...

Sterol regulatory element-binding protein (SREBP)-1a is a unique mem-brane-bound transcription factor highly expressed in actively growing cells and involved in the biosynthesis of cholesterol, fatty acids, and phospholip-ids. Because mammalian cells need to synthesize membrane lipids for cell replication, the functional relevance of SREBP-1a in cell proliferation has been considered a biological adaptation.

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors...

Tham khảo tài liệu 'công điện khẩn số 09/cđk-bnn-tt', văn bản luật, tài nguyên - môi trường phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả