Health education for patients is one of the essential tasks of physicians in patient care and treatment. To improve the effectiveness of health care and treatment, physicians must spend more time with patients. The interaction of physicians in performing health education for patients must be really enthusiastic, dynamic and responsive to the needs of each patient.

This study aimed to evaluate the effectiveness and applicability of UBL in the post-operative care of gastrointestinal cancer surgery for patients’ family caregivers at Department of Surgery 1, Da Nang Oncology Hospital from April 2020 to February 2022.

Tarocystatin from Colocasia esculenta, a group-2 phytocystatin, is a defense protein against phytopathogenic nematodes and fungi. It is com-posed of a highly conserved N-terminal region, which is homological to group-1 cystatin, and a repetitive peptide at the C-terminus.

Vnd is a dual transcriptional regulator that is essential forDrosophila dor-sal–ventral patterning. Yet, our understanding of the biochemical basis for its regulatory activity is limited. Consistent with Vnd’s ability to repress target expression in embryos, endogenously expressed Vnd physically asso-ciates with the co-repressor, Groucho, inDrosophilaKc167 cells.

NAD is an important cofactor and essential molecule in all living organ-isms. In many eubacteria, including several pathogens, the first two steps in the de novosynthesis of NAD are catalyzed byl-aspartate oxidase (NadB) and quinolinate synthase (NadA). Despite the important role played by these two enzymes in NAD metabolism, many of their biochemical and structural properties are still largely unknown.

A key limitation of whole-cell redox biocatalysis for the production of valuable, specifically functionalized products is substrate⁄product toxicity, which can potentially be overcome by using solvent-tolerant micro-organ-isms.

Tham khảo luận văn - đề án 'báo cáo khoa học: s100–annexin complexes – structural insights', luận văn - báo cáo, báo cáo khoa học phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

Herpes simplex virus 1 (HSV-1) demonstrates a unique ability to infect a variety of host cell types. Retinal pigment epithelial (RPE) cells form the outermost layer of the retina and provide a potential target for viral inva-sion and permanent vision impairment.

An NADH oxidase (NOX) was cloned from the genome ofThermococ-cus profundus (NOXtp) by genome walking, and the encoded protein was purified to homogeneity after expression in Escherichia coli.Subsequent analyses showed that it is an FAD-containing protein with a subunit molecular mass of 49 kDa that exists as a hexamer with a native molecular mass of 300 kDa.

RepA, the replication initiator protein from thePseudomonasplasmid pPS10, regulates plasmid replication and copy number. It is capable of autorepression, in which case it binds as a dimer to the inverted repeat oper-ator sequence preceding its own gene.

The hypothalamic decapeptide gonadotropin-releasing hormone (GnRH) is well known for its role in the control of pituitary gonadotropin secretion, but the hormone and receptor are also expressed in extrapituitary tissues and tumor cells, including epithelial ovarian cancers.

We investigated hypoxia-inducible factor (HIF)-dependent changes in the expression of 5592 genes in response to hypoxia (0.1% O2, 16 h) by per-forming cDNA microarray analyses of mouse hepa1c1c7 and BpRc1 cells. BpRc1 cells are a hepa1c1c7 variant defective in HIF-b⁄aryl hydrocarbon receptor nuclear translocator (Arnt), and are therefore unable to induce HIF target genes in response to hypoxia.

A set of thirty-two natural and ten semisynthetic ecdysteroids was assayed in murine 3T3 cells across ten different ecdysteroid receptor (EcR) ligand-binding domains derived from nine arthropod species in an engineered gene switch format. Among the ecdysteroids tested, the most biologically wide-spread ecdysteroid, 20-hydroxyecdysone (20E), was moderately and consis-tently potent across the tested EcRs.

Exploiting specific targets is of specific interest in developing eco-friendly pesticides. We isolated, purified and characterized a novel b-N-acetyl-d-hexosaminidase (OfHex1) from the fifth instar larva integument of the Asian corn borer,Ostrinia furnacalis(Guene´e). OfHex1 was purified 1468-fold to homogeneity with an activity yield of 20% by four column chroma-tography steps.

Tyr235 of GTP-dependent phosphoenolpyruvate (PEP) carboxykinase is a fully invariant residue. The aromatic ring of this residue establishes an energetically favorable weak anion–quadrupole interaction with PEP carboxylate. The role of Tyr235 in catalysis was investigated via kinetic analysis of site-directed mutagenesis-derived variants.

Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the dif-ferent PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis.

Okadaic acid (OA) and its analogs, the dinophysistoxins, are potent inhibi-tors of protein phosphatases 1 and 2A. This action is well known to cause diarrhea and gastrointestinal symptons when the toxins reach the digestive tract by ingestion of mollusks. A less well-known effect of these group of toxins is their effect in the cytoskeleton.

Small heat shock proteins (sHsps) are intracellular molecular chaperones that prevent the aggregation and precipitation of partially folded and destabilized proteins. sHsps comprise an evolutionarily conserved region of 80–100 amino acids, denoted thea-crystallin domain, which is flanked by regions of variable sequence and length: the N-terminal domain and the C-terminal extension.

Hypoxic preconditioning may afford protection against subsequent lethal hypoxia. As hypoxic tolerance induces changes in the expression of genes involved in DNA damage and repair response pathways, we investigated whether DNA-dependent protein kinase (DNA-PK), one of the DNA dou-ble-strand break repair proteins, could be involved in hypoxic precondi-tioning-induced protective signaling cascades.

Alzheimer’s disease (AD) is a neurological disorder characterized by the presence of amyloidb(Ab) peptide fibrils and oligomers in the brain. It has been suggested that soluble Ab oligomers, rather than Ab fibrils, contribute to neurodegeneration and dementia due to their higher level of toxicity.