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Kết quả từ khoá "Hypoxanthine"
0 trang
51 lượt xem
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Báo cáo khoa học: Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase Stability studies on the product-activated enzyme
Hypoxanthine guanine phosphoribosyltransferases (HGPRTs) catalyze the conversion of 6-oxopurine bases to their respective nucleotides, the phos-phoribosyl group being derived from phosphoribosyl pyrophosphate. RecombinantPlasmodium falciparumHGPRT, on purification, has negli-gible activity, and previous reports have shown that high activities can be achieved upon incubation of recombinant enzyme with the substrates hypo-xanthine and phosphoribosyl pyrophosphate [Keough DT, Ng AL, Winzor DJ, Emmerson BT & de Jersey J (1999)Mol Biochem Parasitol98, 29–41; Sujay Subbayya IN & Balaram H (2000)Biochem Biophys Res Commun 279, 433–437]. ...
awards
8 trang
34 lượt xem
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Báo cáo khoa học: Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant ) insights into inhibitor design
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a potential target for structure-based inhibitor design for the treatment of parasitic dis-eases. We created point mutants of Thermoanaerobacter tengcongensis HGPRT and tested their activities to identify side chains that were impor-tant for function.
media19
8 trang
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Báo cáo khoa học:Spectrophotometric Determination of Allopurinol in Tablet Formulation
Allopurinol (1H-pyrazolo[3,4-d]pyrimidin-4-ol) (Fig. 1) is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy, antineoplastic agents and treatment with diureticsconditions.1 Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and acts to inhibit xanthine oxidase. In the presence of xanthine oxidase, allopurinol will be converted to alloxanthine (Fig. 2), after that the formation of uric acid from xanthine and hypoxanthine will be inhibited....
hoami_266
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Báo cáo khoa học:Perfect Matching Preservers
A subset M  E(G) of the edge set E(G) of a graph G is called a matching provided that no two edges in M have a vertex in common. A perfect matching M is a matching with the property that each vertex of G is incident with an edge in M. For k a positive integer, a graph G is k-extendable provided that G has a matching of size k and every matching in G of size at most k can be extended to a perfect matching in G.
thulanh6
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Báo cáo khoa học:Nilpotent Singer groups
Let N be a nilpotent group normal in a group G. Suppose that G acts transitively upon the points of a nite non-Desarguesian projective plane P. We prove that, if P has square order, then N must act semi-regularly on P. In addition we prove that if a nite non-Desarguesian projective plane P admits more than one nilpotent group which is regular on the points of P then P has non-square order and the automorphism group of P has odd order.
thulanh6
18 trang
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Báo cáo khoa học:Restricted walks in regular trees
Let T be an in nite regular tree and n a positive integer. Fix two vertices x and y in T . By a walk or a path between x and y we mean any nite sequence of edges that connect x and y in which backtrackings are allowed. There are many formulas in the literature which give the number of walks of length n between x and y, such as recurrence formulas, generating functions, Green functions, and others. Here we consider walks of length n between x and y which at a certain time follow a number of predetermined steps....
thulanh6

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