This study explores phytochemical profiles and several biological activities of Santalum album L. flowers collected from Dak Lak Province, Vietnam. The qualitative phytochemical analysis of Santalum album flower extracts reveals the presence of free triterpenoids, flavonoids, and tannins, particularly in the alcohol and water extracts, suggesting a rich source of bioactive compounds with potential therapeutic benefits, while other compound groups like saponins, alkaloids, coumarins, and essential oils are either absent or present in very low concentrations.