Hội chứng kháng phospholipid (APS) được xác định bởi sự xuất hiện của các kháng thể kháng phospholipids (aPLs) và huyết khối động hoặc tĩnh mạch, sẩy thai tái diễn, hoặc giảm tiểu cầu. Hội chứng có thể là tiên phát hoặc thứ phát, thường gặp nhất trong bệnh lupus ban đỏ hệ thống (SLE). Nghiên cứu siêu âm tim phát hiện ra bất thường van tim ở 1/3 bệnh nhân APS tiên phát.

It is known that phosphatidylinositol (PtdIns) contains abundant arachidonate and is composed mainly of 1-stea-royl-2-arachidonoyl species in mammals. We investigated if this characteristic of PtdIns applies to the PtdIns from yellowtail (Seriolaquinqueradiata),amarinefish. Incommon with phosphatidylcholine (PtdCho),phosphatidylethanol-amine (PtdEtn) andphosphatidylserine (PtdSer) frombrain, heart,liver,spleen,kidney and ovary,the predominant polyunsaturated fatty acid was docosahexaenoic acid,and levels of arachidonic acid were less than 4.5% (PtdCho), 7.5%(PtdEtn) and3.0%(PtdSer) in these tissues....

Uniquely amongst vitamin K-dependent coagulation proteins, protein C interacts via its Gla domain both with a receptor, the endothelial cell protein C receptor (EPCR), and with phospholipids. We have studied naturally occurring and recombinant protein C Gla domain variants for soluble (s)EPCR binding, cell surface activation to activated protein C (APC) by the thrombin–thrombomodulin complex, and phospholipid dependent factor Va (FVa) inactivation by APC, to establish if these functions are concordant. ...

Model amphipathic peptides have been widely used as a tool to determine the structural and biological properties that control the interaction of pep-tides with membranes. Here, we have focused on the role of a central Pro in membrane-active peptides. To determine the role of Pro in structure, antibiotic activity, and interaction with phospholipids, we generated a ser-ies of model amphipathic a-helical peptides with different chain lengths and containing or lacking a single central Pro.

Recently, we identified Ala426 and Lys438 of phospholipase D fromStrep-tomyces septatus TH-2 (TH-2PLD) as important residues for activity, sta-bility and selectivity in transphosphatidylation. These residues are located in a C-terminal flexible loop separate from two catalytic HxKxxxxD motifs.

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo...