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A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis

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Comprehensive protein-protein interaction (PPI) maps are a powerful resource for uncovering the molecular basis of genetic interactions and providing mechanistic insights. Over the past decade, high-throughput experimental techniques have been developed to generate PPI maps at proteome scale, first using yeast two-hybrid approaches and more recently via affinity purification combined with mass spectrometry (AP-MS).

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Nội dung Text: A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis

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