Moät soá virus gaây beänh quan troïng
trong thuù y
Chương 3:
Rhabdoviridae
Order Mononegavirales
The Mononegavirales are an order of viruses comprising
species that have anon-segmented, negative sense RNA
genome.The order includes four families:
➢Bornaviridae (Borna disease)
➢Filoviridae (e.g., Marburg virus, Ebola virus)
➢Paramyxoviridae (e.g., Newcastle disease virus,
measles virus)
➢Rhabdoviridae (e.g., Rabies virus)
Hoï Rhabdoviridae
❖Virion coù hình vieân ñaïn, aùo ngoaøi goàm 2 lôùp
vôùi nhieàu glycoprotein peplomers, kích thöôùc
70 x170 nm
❖Nuclecapsid coù caáu truùc ñoái xöùng xoaén
❖Genome: ssRNA linear, negative, 11-15 kb
Boä gen maõ hoaù 5 protein: Transcriptase L,
Glycoprotein G, Nucleoprotein N, Matrix
protein Mvaø Protein NS
General structure of a Rhabdovirus
The cross-sectional diagram demonstrates the concentric
layers: envelope membrane bilayer, M protein, and tightly coiled
encased genomic RNA.
Nucleoprotein
Envelope
membrane
Matrix protein