Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor
Molecular mechanics calculations on conformers of
Ac-HGly-NHMe, Ac-b
2
-HAla-NHMe and Ac-b
3
-HAla-NHMe indicate that low-energy conformations of the
b-amino acids backbone, corresponding to gauche rotamers
around the Ca–Cbbond, may overlap canonical backbone
conformers observed for a-amino acids. Therefore, Sub-stance P (SP) was used as a model peptide to analyse the
structural and biological consequences of the substitution of
Phe7andPhe8by(R)-b
2
-HPheandofGly9byHGly (R)-b
2
-HAla or (S)-b
3
-HAla....
