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Lipopolysaccharide
Báo cáo khoa học: Novel synthetic gluco-disaccharide RSCL-0409 – a lipopolysaccharide-induced Toll-like receptor-mediated signalling antagonistThe regulation of cytokines and pro-inflammatory genes is an absolute
essentiality to combat inflammatory diseases. The present study investigated
the effects of 4-O-chloroacetyl-2,3-di-O-acetyl-6-O-levulinoyl-b-d-glucopyr-anosyl]-(1-3)-1-O-(p-methoxyphenyl)-2-deoxy-2-N-trichloroacetyl-4,6-O-ben-zylidene-a-d-glucopyranoside (RSCL-0409), a novel small molecule Toll-like
receptor (TLR) signalling antagonist, and its mechanism of action in human
monocytic (THP-1) cells stimulated with lipopolysaccharide (LPS)....
Báo cáo khoa học: The chromosomal protein HMGN2 mediates lipopolysaccharide-induced expression of b-defensins in A549 cellsHumanb-defensin-2 (HBD-2) is an antimicrobial peptide produced by the
epithelial cells that plays an important role in innate and adaptive immu-nity. Here we report that high mobility group protein N2 (HMGN2), a
member of the high mobility group superfamily that affects chromatin
function, modulates the expression of HBD-2 in A549 cells treated by lipo-polysaccharide.
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Báo cáo khoa học: Human lactoferrin activates NF-jB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signalingLactoferrin (LF) has been implicated in innate immunity. Here we reveal
the signal transduction pathway responsible for human LF (hLF)-triggered
nuclear factor-jB (NF-jB) activation. Endotoxin-depleted hLF induces
NF-jB activation at physiologically relevant concentrations in the human
monocytic leukemia cell line, THP-1, and in mouse embryonic fibroblasts
(MEFs).
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Báo cáo khoa học: Regulatory feedback loop between NF-jB and MCP-1-induced protein 1 RNaseA novel geneZC3H12A, encoding MCP-1-induced protein 1 (MCPIP),
was recently identified in human peripheral blood monocytes treated with
monocyte chemotactic protein 1 (MCP-1) and in human monocyte-derived
macrophages stimulated with interleukin (IL)-1b. These experiments
revealed that the gene undergoes rapid and potent transcription induction
upon stimulation with proinflammatory molecules, such as MCP-1, IL-1b,
tumour necrosis factor aand lipopolysaccharide.
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