CLINICAL PHARMACOLOGY 2003 (PART 27)

Correction of blood lipid abnormalities offers scope for a major impact on cardiovascular disease. Drugs play a significant role and have a variety of modes of action. Dietary and lifestyle adjustment are components of overall risk prevention. • Pathophysiology • Primary (inherited) and secondary hyperlipidaemias • Management: risk assessment, secondary and primary prevention, drugs, diet, lifestyle • Drugs used in treatment: statins; fibric acid derivatives; anion-exchange resins; nicotinic acid and derivatives SOME PATHOPHYSIOLOGY The normal function of lipoproteins is to distribute and recycle cholesterol. ...