Báo cáo khoa học: Proteomic characterization of lipid raft proteins in amyotrophic lateral sclerosis mouse spinal cord
Familial amyotrophic lateral sclerosis (ALS) has been linked to mutations
in the copper⁄zinc superoxide dismutase (SOD1) gene. The mutant SOD1
protein exhibits a toxic gain-of-function that adversely affects the function
of neurons. However, the mechanism by which mutant SOD1 initiates ALS
is unclear.