Nghiên cứu tác dụng của nano alginate/chitosan/lovastatin lên học tập, trí nhớ trên chuột cống gây mô hình béo phì

The global prevalence of obesity is a pressing public health concern, extending beyond metabolic and cardiovascular complications to increasingly impact cognitive functions, including locomotion, exploration, learning, and memory. Traditional treatments for related cognitive deficits, such as Lovastatin, face limitations due to their short half-life and suboptimal bioavailability, necessitating advanced delivery systems. This study addresses this critical gap by investigating the therapeutic potential of a novel Nano Alginate/Chitosan/Lovastatin complex. The primary objective is to evaluate its efficacy in improving cognitive and motor activities in obese rat models, offering a promising avenue for enhanced pharmacological intervention.

Academics and researchers in pharmacology, neuroscience, obesity, nutrition, and drug delivery systems; clinicians interested in cognitive impairments related to metabolic disorders.

This study investigated the potential of a Nano Alginate/Chitosan/Lovastatin complex to enhance locomotion, exploration, and recognition activities in white rats rendered obese by a high-fat diet. Sixty male rats, after a 7-week obesity induction, were randomly assigned to six groups: normal diet with salt water, Lovastatin, or Nano/Lovastatin, and high-fat diet with salt water, Lovastatin, or Nano/Lovastatin. Following a 12-week intervention, rat behaviors were assessed using the Morris water maze. Results indicated that all three drug treatment groups, regardless of diet, showed reduced travelled distance and time to locate the platform over the training days, suggesting improved learning. While statistical analysis showed no significant overall interaction effect between drug groups and diet, a notable trend emerged: the B-Nano/Lovastatin group, representing high-fat diet rats treated with the nano complex, exhibited less time to find the platform in the final training days compared to the B-Lovastatin and B-NaCl groups. This suggests a specific benefit in an obese context. The findings conclude that the Nano Alginate/Chitosan/Lovastatin complex effectively improves learning and spatial memory in obese rats. However, no significant effect on memory recall (retrieval) was observed. This research highlights the promising therapeutic role of nanotechnology-enhanced drug delivery for addressing cognitive impairments associated with obesity, particularly in learning and spatial navigation, although further investigation into long-term memory effects is warranted.