Leukemia

Bệnh bạch cầu (Leukemia): bệnh ác tính của cơ quan tạo máu, đặc trưng bởi sự tăng sinh bất thường của các tế bào dòng bạch cầu và các tế bào tiền thân trong máu và tủy xương. Phân loại Leukemia: thời gian sống trung bình - mức độ trưởng thành của tế bào. Leukemia cấp: tế bào chưa trưởng thành; Leukemia mạn tính: tế bào trưởng thành hơn.

57p sony_12 26-06-2013 571 79   Download

Bài giảng Những rối loạn tăng sinh tủy (Myeloproliferative neoplasms) trình bày những nội dung chính như: Bạch cầu mạn dòng tủy (chronic myelogenous leukemia: CML), đa hồng cầu nguyên phát (Polycythemia vera: PV), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET), tăng tiểu cầu nguyên phát (Essential thrombocythemia: ET). Mời các bạn cùng tham khảo.

57p tangtuy04 23-03-2016 101 10   Download

Bài giảng Sinh lý bệnh máu và tạo máu được biên soạn với mục tiêu giúp các bạn học có thể nêu khái niệm, định nghĩa thiếu máu; trình bày cách xếp loại, cơ chế, đặc điểm, biểu hiện của thiếu máu; nêu được biện pháp thích nghi của cơ thể khi thiếu máu; trình bày cơ chế tăng, giảm các loại bạch cầu máu; trình bày nguyên nhân, cách xếp loại, tên gọi bệnh Leukemia;...Mời các bạn cùng tham khảo!

105p thuyduong0620 09-07-2024 6 2   Download

The research project deals with two different types of data for two separate analysis. The first analysis deals with normalised RNA-seq breast cancer data where machine learning techniques are used to classify and identify the biomarker of cancer. Second analysis deals with raw DNA methylated leukemia samples to determine the mutations.

102p runthenight04 02-02-2023 8 4   Download

Mục tiêu của đề tài là hoàn thiện quy trình kỹ thuật RT - PCR để xác định đột biến ở các gen NPM1-mutA và FLT3 trong leukemia cấp dòng tủy; khảo sát tỷ lệ đột biến NPM1-mutA và FLT3 ở người bệnh leukemia cấp dòng tủy được thu thập tại Viện Huyết học – Truyền máu Trung ương trong thời gian từ tháng 8/2017 đến tháng 7/2018.

73p beloveinhouse03 22-08-2021 17 4   Download

Amplification of N-myc oncogene is a frequent event in advanced stages of human neuroblastoma and correlates with poor prognosis and enhanced neovascularization. Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies, which is modulated by tumor suppressors and oncogenes. We have addressed the possibility that N-myc oncogene might regulate angiogenesis in neuroblastoma. Here, we report that experimental N-Myc overexpression results in down-regulation of leukemia inhibitory factor (LIF), a modulator of endothelial cell proliferation....

10p system191 01-06-2013 35 4   Download

Department of Physiology, University of Basel, Switzerland; 2Department of Biophysical Chemistry, Biocenter, University of Basel, Switzerland; 3Xerion Pharmaceuticals, Martinsried, Germany; 4Department of Medicine, Section Pathophysiology, Johannes Gutenberg University of Mainz, Germany; 5Department of Biochemistry, Christian Albrechts University of Kiel, Germany Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro. ...

9p system191 01-06-2013 40 4   Download

gp130 is the common signal transducing receptor subunit of interleukin (IL)-6-type cytokines. gp130 either homodimerizes in response to IL-6 and IL-11 or forms heterodimers with the leukemia inhibitory factor (LIF) receptor (LIFR) in response to LIF, oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1) or cardiotrophinlike cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades. The extracellular parts of both gp130 and LIFR consist of several Ig-like and fibronectin type III-like domains.

11p system191 01-06-2013 45 4   Download

Subunits (a, b and c) of the interleukin-2 receptor complex (IL-2R) are involved in both proliferative and activationinduced cell death (AICD) signaling of T cells. In addition, the signaling b and c chains are shared by other cytokines (e.g. IL-7, IL-9, IL-15). However, the molecular mechanisms responsible for recruiting/sorting the a chains to the signaling chains at the cell surface are not clear.

10p research12 01-06-2013 30 5   Download

We have recently expressed in bacteria the enzymatically active reverse transcriptase (RT) of bovine leukemia virus (BLV) [Perach, M. & Hizi, A. (1999) Virology 259, 176–189]. In the present study, we have studied in vitro two features of the DNA polymerase activity of BLV RT, the processivity of DNA synthesis and the fidelity of DNA synthesis. These properties were compared with those of the well-studied RTs of human immunodeficiency virus type 1 (HIV-1) and murine leukaemia virus (MLV).

9p research12 01-06-2013 43 4   Download

Undifferentiated human promyelocytic leukemia HL-60 cells show little or no superoxide production, but generate a very low O2 – concentration upon incubation with all-trans-retinoic acid (ATRA). Its production reaches a maximum within 20 h, and thereafter is maintained at an almost con-stant level. The differentiated cells show phorbol 12-myri-state 13-acetate (PMA)-stimulatedNADPHoxidase activity consistent with the amount of gp91phox(phagocytic oxid-ase) expressed in the plasma membrane.

8p research12 29-04-2013 36 5   Download

Eosinophil cationic protein (ECP), one of the major components of basic granules of eosinophils, is cytotoxic to tracheal epithelium. However, the extent of this e€ect on other cell types has not been evaluatedin vitro.Inthis study, we evaluated the e€ect of ECP on 13 mammalian cell lines. ECP inhibited the growth of several cell lines including those derived from carcinoma and leukemia in a dose-dependent manner.

10p research12 29-04-2013 36 4   Download

The heterodimeric cytokine composed of the soluble ciliary neurotrophic factor receptor (sCNTFR) and the IL-6 family member cardiotrophin-like cytokine (CLC) was recently identi®ed as a new ligand for gp130±leukemia inhibitory factor receptor (LIFR) complex [Plun-Favreau, H., Elson, G., Chabbert, M., Froger, J., deLapeyriere, O., Lelievre, E., Guillet, C., Hermann, J., Gauchat, J. F., Gascan, H. & Chevalier, S. (2001)EMBO J.20, 1692± 1703]. This heterodimer shows overlapping biological properties with LIF....

10p research12 23-04-2013 29 2   Download

Zinc (Zn), an endogenous regulator of apoptosis, and has abilitiesboth to induceapoptosis and inhibit the inductionof apoptosis via the modulation of caspase activity. Due to the multifunctions of Zn, the intracellular Zn level is strictly regulated by a complex system in physiological and patho-logical conditions. The commitment of Zn to the regulation of apoptosis is not fully understood. In the present study, we investigated the role of intracellular Zn level in the induction of apoptosis in human leukemia cells (HL-60 cells) using a Zn ionophore [pyrithione (Py)]....

8p tumor12 22-04-2013 29 2   Download

The transcription factor v-Myb is a potent inducer of myeloid leukemias, and its cellular homologue c-Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and coworkers (Bies, J., Markus, J. & Wolff, L. (2002)J. Biol. Chem, 277, 8999–9009) presented evidence that murine c-Myb can be sumoylated under overexpression conditions in COS7 cells when cotrans-fected with FLAG-tagged SUMO-1.

11p tumor12 20-04-2013 38 3   Download

Integrase (IN) is the retroviral enzyme responsible for the integration of the DNA copy of the retroviral genome into the host cellDNA. TheC-terminal domainof INis involved in DNA binding and enzyme multimerization. We previ-ously performed single amino acid substitutions in the C-terminal domain of the avian leukemia and sarcoma vir-uses (ALSV) IN [Moreauet al. (2002). Arch. Virol.147, 1761–1778].

13p fptmusic 12-04-2013 44 4   Download

Bacterial l-asparaginases are enzymes that catalyze the hydrolysis of l-asparagine to aspartic acid. For the past 30 years, these enzymes have been used as therapeutic agents in the treatment of acute childhood lymphoblastic leukemia.

11p galaxyss3 07-03-2013 46 4   Download

The humanmyeloid leukemia factor 1(hMLF1) gene was first identified as anNPM–hMLF1fusion gene produced by chromosomal translocation. In Drosophila, dMLF has been identified as a protein homologous to hMLF1 and hMLF2, which interacts with various factors involved in transcrip-tional regulation.

13p media19 05-03-2013 37 3   Download

Vitamin K2(menaquinone-4, MK-4) has been reported to induce apoptosis in hepatocellular carcinoma, leukemia and myelodysplastic syndrome cell lines. The effects of MK-4 on the development of arthritis have never been addressed thus far. In the present study, we investigated the effect of MK-4 upon the proliferation of rheumatoid synovial cells and the development of arthritis in collagen-induced arthritis.

7p media19 04-03-2013 27 4   Download

HOXC13, a homeobox-containing gene, is involved in hair development and human leukemia. The regulatory mechanism that drives HOXC13 expression is mostly unknown. Our studies have demonstrated that HOXC13 is transcriptionally activated by the steroid hormone estrogen (17b-estradiol; E2).

12p vinaphone15 28-02-2013 49 2   Download