Bài giảng Hở van hai lá, được biên soạn gồm các nội dung chính sau: nguyên nhân bệnh lý van 2 lá; bệnh lý vòng van 2 lá; bệnh lý dây chằng; bệnh lý cột cơ; Cơ chế huyết động học trong HoHL cấp; Huyết động học trong HoHL cấp và mạn tính; triệu chứng lâm sàng;...Mời các bạn cùng tham khảo!

Synaptophysin, one of the major proteins on synaptic vesi-cles, is ubiquitously expressed throughout the brain. Syn-aptophysin and synapsin I, another synaptic vesicle protein, are also expressed by retinoic acid-induced neuronally dif-ferentiated P19 teratocarcinoma cells. Here, we show that inhibition of histone deacetylase activity in P19 cells is suf-ficient to activate transcription of the synaptophysin and synapsin I genes, indicating that neuronal differentiation and impairment of histone deacetylases results in a similar gene expression pattern....

Research on the regulation of transcription in mammals initially focused on the mechanism of transcriptional acti-vation and
positive control of gene regulation. In contrast, transcriptional repression and
negative control of gene transcription was viewed rather as part of the
prokaryotic book of biology. However, results obtained in recent years have shown convincingly that transcriptional repression mediated by repressor proteins is a common regulatory mechanism in mammals and may play a key role in many biological processes. ...