Kết quả điều trị và một số yếu tố liên quan đến rối loạn đông máu ở trẻ sơ sinh nhiễm khuẩn huyết tại Bệnh viện Nhi Hải Phòng

Neonatal sepsis represents a critical global health challenge, contributing significantly to morbidity and mortality among infants, particularly in developing regions. This severe infection often leads to a spectrum of complications, with coagulation disorders being particularly concerning due to their potential to exacerbate illness severity and increase the risk of adverse outcomes. The intricate interplay between systemic infection and the coagulation cascade can disrupt hemostasis, resulting in diverse clinical manifestations ranging from minor bleeding to life-threatening hemorrhage. Given the profound impact of these disorders on neonatal survival and long-term health, early identification and effective management are paramount. This study, conducted at Hai Phong Pediatric Hospital, aims to evaluate the treatment outcomes and delineate key factors associated with coagulation disorders in neonates diagnosed with sepsis, providing crucial insights for clinical practice.

Medical professionals specializing in pediatrics and neonatology, researchers focusing on infectious diseases and hematology in newborns, and public health officials concerned with infant mortality and health outcomes.

This case series study investigated treatment outcomes and factors associated with coagulation disorders in 32 neonates diagnosed with culture-proven sepsis at Hai Phong Pediatric Hospital between August 2023 and September 2025. The research aimed to provide a comprehensive understanding of the challenges faced in managing neonatal sepsis and its hematological complications. The study revealed that 71.9% of the neonates were successfully treated and discharged, while a concerning mortality rate of 15.6% was observed. The average treatment duration spanned approximately 25.8 ± 17.7 days, predominantly within 7 to 28 days. A significant finding was the identification of specific risk factors strongly correlated with coagulation disorders. Preterm infants were found to have a 10.5-fold higher risk compared to full-term neonates. Furthermore, anemic neonates faced a 13-fold increased risk of developing these disorders, and those presenting with bleeding manifestations had a 7-fold higher risk. These findings underscore the critical need for vigilant monitoring and proactive interventions, especially for vulnerable populations such as preterm and anemic infants, and those exhibiting early signs of bleeding. The study's implications are significant for improving diagnostic and management protocols for neonatal sepsis, potentially leading to better patient outcomes and reduced mortality rates by focusing on these identified risk factors for coagulation disorders.