The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the

The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis Ekwall et al. Ekwall et al. Arthritis Research & Therapy 2011, 13:R40 http://arthritis-research.com/content/13/2/R40 (7 March 2011) Ekwall et al. Arthritis Research & Therapy 2011, 13:R40 http://arthritis-research.com/content/13/2/R40 RESEARCH ARTICLE Open Access The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis Anna-Karin H Ekwall1*, Thomas Eisler2, Christian Anderberg3, Chunsheng Jin4, Niclas Karlsson4, Mikael Brisslert1, Maria I Bokarewa1 Abstract Introduction: Activated fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) share many characteristics with tumour cells and are key mediators of synovial tissue transformation and joint destruction....