Khảo sát đặc điểm lâm sàng, cận lâm sàng và tuân thủ điều trị ở người bệnh trào ngược dạ dày – thực quản tại Bệnh viện Lê Văn Thịnh

Gastroesophageal reflux disease (GERD) is a highly prevalent global gastrointestinal condition, impacting an estimated 20% of the population with rising trends, significantly diminishing patients' quality of life and potentially leading to serious complications. Despite advances in diagnosis and therapy, suboptimal treatment adherence remains a significant challenge, with approximately 40% of patients exhibiting poor compliance. Non-adherence, encompassing incorrect medication usage, inadequate lifestyle modifications, and irregular follow-ups, critically undermines treatment efficacy. Given the scarcity of localized data on this issue in Vietnam, this study addresses a critical gap by investigating the clinical and paraclinical characteristics, treatment adherence rates, and associated factors among GERD patients at Le Van Thinh Hospital, thereby contributing to enhanced disease management strategies.

Healthcare professionals, medical researchers, and public health policymakers focused on improving the diagnosis, treatment, and patient adherence for gastroesophageal reflux disease (GERD).

This comprehensive cross-sectional descriptive study investigated the clinical and paraclinical characteristics, treatment adherence rates, and associated factors among 303 adult outpatients diagnosed with gastroesophageal reflux disease (GERD) at Le Van Thinh Hospital. Utilizing the MMAS-8 scale for adherence assessment and multivariate logistic regression analysis, the research aimed to identify key determinants of compliance. The study revealed a patient demographic predominantly female (56.4%) with a mean age of 47.8 years, presenting commonly with heartburn (59.7%) and regurgitation (48.8%). Endoscopic findings indicated that non-erosive reflux disease (NERD) constituted the majority of cases (74.3%). The overall treatment adherence rate was found to be moderate (64%), encompassing both medium and high adherence levels. Crucially, four independent factors were identified as significantly reducing treatment adherence: an increased total daily pill count (OR = 0.79), the presence of anxiety/depression (OR = 0.49), concomitant other gastrointestinal diseases (OR = 0.48), and the persistence of regurgitation symptoms (OR = 0.43). These findings underscore that while typical clinical manifestations are common, NERD is prevalent, and adherence remains a challenge. The study’s implications are significant for improving GERD management, emphasizing the necessity of optimizing medication regimens to reduce pill burden, screening for and managing mental health comorbidities like anxiety and depression, addressing co-occurring gastrointestinal conditions, and providing targeted patient education, particularly for those experiencing regurgitation symptoms. These efforts are crucial for enhancing patient compliance and ultimately improving treatment efficacy and patient outcomes.