Phân bố kiểu genotyp HPV ở bệnh nhân nam giới mắc tại Bệnh viện Hữu nghị Việt Đức

Human Papillomavirus (HPV) infection is a globally prevalent sexually transmitted infection (STI) with significant health implications. While often transient, persistent HPV infections can lead to a spectrum of conditions, from benign genital warts to various cancers. Historically, research has largely focused on female populations and cervical cancer, but there is growing recognition of the substantial burden on male populations, who serve as reservoirs for transmission and are susceptible to HPV-related diseases, including warts and anogenital cancers. In Vietnam, the epidemiological landscape of STIs, particularly genital warts, is evolving, yet comprehensive data on HPV genotype distribution among men remains limited. This study aims to address this critical knowledge gap, emphasizing the importance of understanding the local HPV epidemiology to inform effective public health strategies and clinical management.

Healthcare professionals (dermatologists, urologists, infectious disease specialists), public health officials, epidemiologists, and researchers involved in sexually transmitted infections and oncology in Vietnam.

This cross-sectional descriptive study investigated the clinical characteristics, HPV genotype distribution, and associated factors in 110 male patients diagnosed with genital warts at Viet Duc University Hospital. Utilizing Real-time PCR for genotyping, the research aimed to provide crucial epidemiological insights into HPV infection patterns in the Vietnamese male population. The findings revealed that patients exhibited high-risk sexual behaviors, with a mean age of 33.7 years, and a high prevalence (90.1%) of multiple sexual partners. A significant proportion (53.6%) experienced co-infection with multiple HPV genotypes. While low-risk genotypes such as HPV 11 (41.8%) and HPV 6 (30.0%) were the most common causes of genital warts, the presence of high-risk genotypes, including HPV 56 (11.8%), HPV 51 (10.9%), and HPV 16 (10.0%), was also notably significant. A key association was identified between a history of sexually transmitted diseases and high-risk HPV infection (p < 0.05), underscoring the role of sexual behaviors in HPV acquisition and persistence. This study highlights the need for robust counseling, screening, and genotyping in the management of male genital warts patients, as clinical presentation alone may not reliably predict the presence of high-risk types. The results strongly advocate for the expansion of public health initiatives, particularly HPV vaccination programs for men, to mitigate the future burden of HPV-related diseases in Vietnam.