To evaluate the prevalence of sarcopenia and its associated factors in lung cancer patients undergoing chemotherapy at a tertiary hospital in Vietnam. Methods: A cross-sectional descriptive study was conducted on 89 lung cancer patients. Sarcopenia was assessed using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria, including measurements of handgrip strength (HGS), appendicular skeletal muscle mass (ASM), and physical performance.

Skeletal muscle-related studies have recently been applied in the combat of obesity and metabolic disorders. Culture skeletal muscle cells in in vitro plays an important role in being a promising model for those researches. In the present study, the C2C12 skeletal muscle cells were grown and differentiated in in vitro.

Bài giảng với các nội dung: Achondrogenesis, các dấu hiệu siêu âm bất sản sụn, kiểm soát lâm sàng, chăm sóc sau sanh, dấu hiệu siêu âm loạn sản sụn, hội chứng dải sợi ối, Arthrogryposis Multiplex Congenita...

Ikkai&Ooi [Ikkai,T.&Ooi,T. (1966)Biochemistry5, 1551± 1560] made a thorough study of the e€ect of pressure on G- and F-actins. However, all of the measurements in their study were made after the release of pressure. In the present experiment in situ observations were attempted by using eATP to obtain further detailed kinetic and thermodynamic information about the behaviour of actin under pressure.

The goal of this study was to relate conformational changes in the N-terminal domain of chicken troponin I (TnI) to Ca 2+ activation of the actin–myosin interaction.The two cysteine residues in this region (Cys48 and Cys64) were labeled with two sulfhydryl-reactive pyrene-containing fluorophores [N-(1-pyrene)maleimide, and N-(1-pyrene)-iodoacetamide].The labeled TnI showed a typical fluores-cence spectrum: two sharp peaks of monomer fluorescence and a broad peak of excimer fluorescence arising from the formation of an excited dimer (excimer)....

Calpain 1, a ubiquitous calcium-dependent intracellular protease, was recently found in a tight association with myofibrils in skeletal muscle tis-sue [Delgado EF, Geesink GH, Marchello JA, Goll DE & Koohmaraie M (2001) J Anim Sci79, 2097–2107). Our immunofluorescence and immuno-electron microscopy investigations restrain the protease location at the per-iphery of the Z-band and at the midpoint of the I-band.

Duchenne muscular dystrophy represents one of the most common hereditary diseases. Abnormal ion handling is believed to render dystrophin-deficient muscle fibres more susceptible to necrosis. Although a reduced Ca 2+ buffering capacity has been shown to exist in the dystrophic sarco-plasmic reticulum, surprisingly no changes in the abundance of the main luminal Ca 2+ reservoir protein calsequestrin have been observed inmicrosomal preparations.

The effect of gadolinium ions on the sarcoplasmic reticulum (SR) calcium release channel⁄ryanodine receptor (RyR1) was studied using heavy SR (HSR) vesicles and RyR1 isolated from rabbit fast twitch muscle. In the [ 3 H]ryanodine binding assay, 5lmGd 3+ increased the Kd of the [ 3 H]ry-anodine binding of the vesicles from 33.8 nmto 45.6 nmwhileBmax, refer-ring to the binding capacity, was not affected significantly. In the presence of 18 nm[ 3 H]ryanodine and 100lmfree Ca 2+ ,Gd 3+ inhibited the binding of the radiolabeled ryanodine with an apparentKd value of 14.7lmand a Hill coefficient of 3.17. ...

The troponin (Tn) complex is formed by TnC, TnI and TnT and is respon-sible for the calcium-dependent inhibition of muscle contraction. TnC and TnI interact in an antiparallel fashion in which the N domain of TnC binds in a calcium-dependent manner to the C domain of TnI, releasing the inhibitory effect of the latter on the actomyosin interaction. While the crys-tal structure of the core cardiac muscle troponin complex has been deter-mined, very little high resolution information is available regarding the skeletal muscle TnI–TnC complex. ...

Neural stimulation controls the contractile properties of skeletal muscle fibres through transcriptional regulation of a number of proteins, including myosin isoforms. To study whether neural stimulation is also involved in the control of post-translational modifications of myosin, we analysed the phosphorylation of alkali myosin light chains (MLC1) and regulatory myo-sin light chains (MLC2) in rat slow (soleus) and fast (extensor digitorum longus EDL) muscles using 2D-gel electrophoresis and mass spectrometry....

Salmonids utilize a unique, class II isoactin in slow skeletal muscle. This actin contains 12 replacements when compared with those from salmonid fast skeletal muscle, salmonid cardiac muscle and rabbit skeletal muscle. Substitutions are confined to subdomains 1 and 3, and most occur after residue 100. Depending on the pairing, the ‘fast’, ‘cardiac’ and rabbit actins share four, or fewer, substitutions.

Actin–tropomyosin–troponin has three structural states, but the functional properties of regulation can be explained with models having two func-tional states. As a step towards assigning functional properties to all the structural states, we examined fluorescent probes that monitor changes in troponin and tropomyosin.

In vertebrates, phosphocreatine and ATP are continuously interconverted by the reversible reaction of creatine kinase in accordance with cellular energy needs. Sarcoma tissue and its normal counterpart, creatine-rich skel-etal muscle, are good source materials to study the status of creatine and creatine kinase with the progression of malignancy.

In an attempt to identify potential therapeutic targets for the correction of muscle wasting, the gene expression of several pivotal proteins involved in protein metabolism was investigated in experimental atrophy induced by transient or definitive denervation, as well as in four animal models of muscular dystrophies (deficient for calpain 3, dysferlin,a-sarcoglycan and dystrophin, respectively).

A multiprotein complex encompassing a transcription regulator, cardiac ankyrin repeat protein (CARP), and the calpain 3 protease was identified in the N2A elastic region of the giant sarcomeric protein titin. The present study aimed to investigate the function(s) of this complex in the skeletal muscle. We demonstrate that CARP subcellular localization is controlled by the activity of calpain 3: the higher the calpain 3, the more important the sarcomeric retention of CARP.

During embryogenesis, most of the mammalian skeletal system is preformed as cartilaginous structures that ossify later. The different stages of cartilage and skeletal development are well described, and several molecular factors are known to influence the events of this enchondral ossification, especially transcription factors.

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Distant metastases of a squamous cell carcinoma of the tongue in peripheral skeletal muscles and adjacent soft tissues

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra-runners - a randomized controlled trial

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Diffuse idiopathic skeletal hyperostosis as an overlooked cause of dysphagia: a case report

ATuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: pplication of different measures of skeletal maturity in initiating weaning from a brace for scoliosis: two case reports