Biến nghiên cứu trở nên có giá trị: Áp dụng PICOT và POEM cho nghiên cứu lâm sàng

Formulating clear and structured research questions is paramount for successful medical studies, yet many clinicians often struggle with this initial phase. This challenge frequently leads to unfocused research with limited practical impact, hindering the translation of scientific inquiry into tangible patient benefits. In response to this critical need, this paper introduces two fundamental frameworks: PICOT and POEM. These tools are indispensable for transforming vague curiosities into precise, answerable questions that are also meaningful and clinically relevant. By emphasizing their role as core principles of Evidence-Based Medicine, this work underscores the importance of a systematic approach to research question formulation to ensure studies yield evidence truly applicable at the bedside.

Clinical practitioners, medical researchers, students of evidence-based medicine, and healthcare policymakers seeking to improve the relevance and impact of clinical research.

This paper comprehensively explores the application of the PICOT and POEM frameworks as foundational pillars for conducting valuable clinical research within the realm of Evidence-Based Medicine. The PICOT framework is presented as a systematic method for structuring clinical research questions, guiding investigators to precisely define the Population, Intervention, Comparison, Outcome, and Time. This structured approach helps transform ambiguous clinical interests into specific, feasible, and measurable research inquiries, crucial for effective study design and literature search. Complementing PICOT, the POEM framework (Patient-Oriented Evidence that Matters) serves as a vital filter for evaluating the worthiness of research questions. POEM emphasizes focusing on outcomes that genuinely improve patient health, such as reduced mortality, enhanced quality of life, or symptom relief, rather than mere surrogate markers like biochemical changes. The paper illustrates how these frameworks can be applied across various research domains, including diagnostics, therapeutics, health economics, and prevention, providing concrete examples. By integrating PICOT and POEM, researchers can ensure their studies not only possess scientific rigor but also generate evidence that is highly relevant, applicable, and directly beneficial to patients. This dual approach bridges the gap between clinical observations and impactful research, ultimately fostering a patient-centered approach that optimizes resource allocation and significantly enhances the real-world utility of medical findings.