Chapter 012. Pain: Pathophysiology and Management (Part 6)
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Antidepressants, anticonvulsants, and antiarrhythmics have not been approved by the U.S. Food and Drug Administration (FDA) for the treatment of pain.bGabapentin in doses up to 1800 mg/d is FDA approved for postherpetic neuralgia.Note: 5-HT, serotonin; NE, norepinephrine.Since they are effective for these common types of pain and are available without prescription, COX inhibitors are by far the most commonly used analgesics. They are absorbed well from the gastrointestinal tract and, with occasional use, have only minimal side effects. With chronic use, gastric irritation is a common side effect of aspirin and NSAIDs and is the problem that most frequently limits...
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