Chapter 109. Disorders of Platelets and Vessel Wall (Part 4)

Table 109-1 Drugs Definitively Reported to Cause Isolated Thrombocytopeniaa Abciximab Digoxin Acetaminophen Eptifibatide Acyclovir Hydrochlorothiazide Aminosalicylic acid Ibuprofen Amiodarone Levamisole Amphotericin B Octreotide Ampillicin Phenytoin Carbamazepine Quinine Chlorpropamide Rifampin Danazol Tamoxifen Diatrizoate meglumine (Hypaque Meglumine) Tirofiban Trimethoprim/sulfamethoxazole Diclofenac Vancomycin a Drugs that preceded thrombocytopenia and full recovery occurred after drug discontinuation, but recurred with re-introduction of the drug, and other causes, including other drugs were excluded. Source: Data from George and colleagues, http://moon.ouhsc.edu/jgeorge. Classic drug-dependent antibodies are antibodies that react with specific platelet surface antigens and result in thrombocytopenia only when the drug is present. ...